Salidroside is an effective adaptogenic extract found from rhodiola species
Effects of salidroside-pretreatment on neuroethology of
rats after global cerebral ischemia-reperfusion.
Zhong Xi Yi Jie He Xue Bao. 2009; Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, China;
To study the effects of salidroside pretreatment on changes of neuroethology in rats with global cerebral ischemia-reperfusion injury so as to investigate its probable mechanism. Sixty SD male rats were randomly divided into sham-operated group, untreated group and salidroside pretreated group. The rats in salidroside pretreated group were intraperitoneally administered with salidroside for seven days. The dose of salidroside was 12 mg/(kg.d). Thirty minutes after the last administration, the acute global cerebral ischemia-reperfusion in rats of the untreated group and the salidroside pretreated group was induced. Our results show salidroside can reduce the degree of cerebral edema of rats with global cerebral ischemia-reperfusion injury, relieve the metabolism abnormity of free radical and improve the function of cognition.
The in vitro and in vivo antiviral effects of
salidroside from Rhodiola rosea L. against coxsackievirus B3.
Phytomedicine. 2009; Department of Chemistry, The Fourth Military Medical University, Xi'an, China.
The aim of this study was to investigate the antiviral effects of salidroside, a major component of Rhodiola rosea L. First, the antiviral effects of salidroside against coxsackievirus B3 (CVB3) were determined in vitro and in vivo. Then, the effect of salidroside on the mRNA expression of some important cytokines was measured in hearts of infected BALB/c mice. Salidroside exhibited obvious antiviral effects both in in vitro and in vivo experiments. Salidroside was found to modulate the mRNA expression of interferon-gamma, interleukin-10 (IL-10), tumor necrosis factor-alpha, and interleukin-2. In conclusion, salidroside possesses antiviral activities against CVB3 and it may represent a potential therapeutic agent for viral myocarditis.
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