Salidroside benefit
Salidroside is an effective adaptogenic extract found from rhodiola species
Effects of salidroside-pretreatment on neuroethology of
rats after global cerebral ischemia-reperfusion.
Zhong Xi Yi Jie He Xue Bao. 2009 Feb; Department of Anesthesiology, Changhai
Hospital, Second Military Medical University, Shanghai 200433, China;
To study the effects of salidroside pretreatment on changes of neuroethology in
rats with global cerebral ischemia-reperfusion injury so as to investigate its
probable mechanism. Sixty SD male rats were randomly divided into sham-operated
group, untreated group and salidroside pretreated group. The rats in salidroside
pretreated group were intraperitoneally administered with salidroside for seven
days. The dose of salidroside was 12 mg/(kg.d). Thirty minutes after the last
administration, the acute global cerebral ischemia-reperfusion in rats of the
untreated group and the salidroside pretreated group was induced. Our results
show salidroside can reduce the degree of cerebral edema of rats with global
cerebral ischemia-reperfusion injury, relieve the metabolism abnormity of free
radical and improve the function of cognition.
The in vitro and in vivo antiviral effects of
salidroside from Rhodiola rosea L. against coxsackievirus B3.
Phytomedicine. 2009 Mar; Department of Chemistry, The Fourth Military Medical
University, Xi'an 710032, China.
The aim of this study was to investigate the antiviral effects of salidroside, a
major component of Rhodiola rosea L. First, the antiviral effects of salidroside
against coxsackievirus B3 (CVB3) were determined in vitro and in vivo. Then, the
effect of salidroside on the mRNA expression of some important cytokines was
measured in hearts of infected BALB/c mice. Salidroside exhibited obvious
antiviral effects both in in vitro and in vivo experiments. Salidroside was
found to modulate the mRNA expression of interferon-gamma, interleukin-10
(IL-10), tumor necrosis factor-alpha, and interleukin-2. In conclusion,
salidroside possesses antiviral activities against CVB3 and it may represent a
potential therapeutic agent for viral myocarditis.