Ribose
sugar
capsule dosage
ribose energy ribose muscle ribose research
Ribose is a carbohydrate, or sugar, used by all living cells and is an essential
component in our body’s energy production.
Ribose has many important roles in physiology. Among them, ribose is a
necessary substrate for synthesis of nucleotides, and it is part of the building blocks
that form DNA and RNA molecules. The amount of
adenosine triphosphate (ATP) stored in muscle tissue available for immediate use
is limited, and once used, needs to be made again in the muscle. Ribose, a
naturally occurring pentose sugar, helps remake ATP for use in muscles.
The claim made is that ribose enhances athletic
performance, but does it?
Click here to buy Ribose supplement product or to sign up to a FREE nutrition
newsletter. For more up to date
ribose research.
Ribose Research Update
Effect of
ribose supplementation on resynthesis of adenine
nucleotides after intense intermittent training in humans.
Hellsten Y. Institute for Excersize and
Sport Science, DK-2100 Copenhagen, Denmark. yhellsten@aki.ku.dk
Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R182-8.
The effect of oral ribose supplementation on the resynthesis of adenine
nucleotides and performance after 1 wk of intense intermittent exercise was
examined. Eight subjects performed a random double-blind crossover design. The
subjects performed cycle training consisting of 15 x 10 s of all-out sprinting
twice per day for 7 days. After training the subjects received either ribose
(200 mg/kg body wt; Rib) or placebo (Pla) three times per day for 3 days. An
exercise test was performed at 72 h after the last training session. Immediately
after the last training session, muscle ATP was lowered by 25 +/- 2
and 22 +/- 3% in Pla and Rib, respectively. In both Pla and Rib, muscle ATP
levels at 5 and 24 h after the exercise were still lower than pretraining. After 72 h, muscle ATP was similar to pretraining in Rib
(24.6 +/- 0.6 vs. 26.2 +/- 0.2 mmol/kg dry wt) but still lower in Pla
(21 vs. 26 mmol/kg dry wt) and higher in Rib than
in Pla. Plasma hypoxanthine levels after the test performed at 72 h were higher in Rib compared with Pla. Mean and peak power outputs during the test
performed at 72 h were similar in Pla and Rib. The results support
the hypothesis that the availability of ribose in the muscle is a limiting
factor for the rate of resynthesis of ATP. Furthermore, the reduction in muscle
ATP observed after intense training does not appear to be limiting for
high-intensity exercise performance.
Effects of oral D-ribose supplementation on
anaerobic capacity and selected metabolic markers in healthy males.
Kreider RB,. Baylor University, Waco, TX 76798-7313, USA.
Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):76-86.
Oral D-ribose supplementation has been reported to increase adenine nucleotide
synthesis and exercise capacity in certain clinical populations. Theoretically,
increasing adenine nucleotide availability may enhance high intensity exercise
capacity. This study evaluated the potential ergogenic value of D-ribose
supplementation on repetitive high-intensity exercise capacity in 19 trained
males. Subjects were familiarized to the testing protocol and performed two
practice-testing trials before pre-supplementation testing. Each test involved
warming up for 5 min on a cycle ergometer and then performing two 30-s Wingate
anaerobic sprint tests on a computerized cycle ergometer separated by 3 min of
rest recovery. In the pre- and post-supplementation trials, blood samples were
obtained at rest, immediately following the first and second sprints, and
following 5 min of recovery from exercise. Subjects were then matched according
to body mass and anaerobic capacity and assigned to ingest, in a randomized and
double blind manner, capsules containing either 5 g of a dextrose placebo (P) or
D-ribose (R) twice daily (10 g/d) for 5 d. Subjects then performed
post-supplementation tests on the 6th day. Data were analyzed by ANOVA for
repeated measures. Results revealed a significant interaction (p =.04) in total
work output. Post hoc analysis revealed that work significantly declined during the second post-supplementation sprint in the P group while
being maintained in the R group. No significant interactions
were observed in peak power, average power, torque, fatigue index, lactate,
ammonia, glucose, or uric acid. Results indicate that oral ribose
supplementation (10 g/d for 5 d) does not affect anaerobic exercise capacity or
metabolic markers in trained subjects as evaluated in this study.
back to Tribulus Terrestris Extract
ribose energy ribose muscle ribose heart ribose research