Activated Quercetin and Bromelain
Source Naturals

Activated Quercetin with bromelain is a unique bioflavonoid derived product from plant sources. In human cell culture studies, Quercetin has been shown to inhibit histamine release. Additional research needs to be conducted to confirm the effects of quercetin, if any, in humans. Bromelain is a pineapple enzyme. Magnesium ascorbate is a buffered (non-acidic) form of vitamin C that helps support the immune system.

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Quercetin Bromelain Supplement Facts:
Vitamin C (as magnesium ascorbate)
Magnesium (as magnesium ascorbate)
Quercetin
Bromelain

Benefits of quercetin
Allergy - Quercetin may be useful for the treatment of mast cell-derived allergic inflammatory diseases.
Cancer -- Quercetin has anti-tumor potential.
Heart disease -- Quercetin inhibits the proliferation and migration of aortic smooth muscle cells, concomitant with inhibition of mitogen-activated protein kinase phosphorylation. These findings provide new insights and a rationale for the potential use of quercetin in the prophylaxis of cardiovascular diseases.
Prostate -- Quercetin my inhibit the proliferation of androgen-independent human prostatic tumor cells.

Quercetin and bone
The effects of quercetin on bone minerals, biomechanical behavior, and structure in streptozotocin-induced diabetic rats.
Cell Biochem Funct. 2007 Jan 31; Department of Histology-Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey.
This study was designed to investigate the effect of quercetin on bone minerals and biomechanics in insulin-dependent diabetic rats. Diabetes was induced by 50 mg kg(-1) intraperitoneal streptozotocin (STZ) in a single dose. The rats were randomly allotted into four experimental groups: A (control), B (non-diabetic + quercetin ), C (diabetic), and D (diabetic + quercetin ) each containing 10 animals. The diabetic rats received quercetin (15 mg kg(-1) day(-1)) for 4 weeks following 8 weeks of STZ injection. It was found that quercetin treatment increased insulin, calcium, and magnesium levels. Three-point bending of the femoral mid-diaphysis and necks showed significantly lower maximum load values (F(max)) in animals in the STZ group than the quercetin + STZ or control groups. The results support the conclusion that quercetin treatment may decrease blood glucose and increase plasma insulin, calcium, and magnesium. Quercetin treatment may also be effective in bone mineral metabolism, biomechanical strength, and bone structure in STZ-induced diabetic rats.

Quercetin in onion and roasting
Thermal Degradation of Onion Quercetin Glucosides under Roasting Conditions.
J Agric Food Chem. 2007 Jan 31; Department of Food Analysis, Institute of Food Technology and Food Chemistry, Technical University of Berlin, Gustav Meyer Allee 25, D-13355 Berlin, Germany.
In this study, the stability of selected model and onion quercetin glycosides under roasting conditions (180 degrees C) was determined. The influence of the kind and position of the sugar moiety was investigated. As onions contain large amounts of quercetin glycosides and are often subject to thermal processes in food production, their major glycosides were isolated using counter current chromatography and roasted. The thermal treatment led to a degradation of the quercetin glycosides. The main product is the aglycone quercetin, which remained stable during further roasting. During the roasting process of the quercetin diglucoside isolated from onion, the formation of a monoglycoside as an intermediate product was observed. This underlined that the stability of the glycosides is dependent on the kind and position of the sugar moiety.

Quercetin Research Update
Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations.
Erlund I, Marniemi J, Hakala P, Alfthan G, Meririnne E, Aro A. Biomarker Laboratory, National Public Health Institute, Helsinki, Finland. Eur J Clin Nutr. 2003 Jan;57(1):37-42.
To study serum quercetin concentrations of subjects consuming berries or habitual Finnish diets. DESIGN: Randomized parallel dietary intervention. Twenty subjects consumed 100 g/day of berries (black currants, lingonberries and bilberries) for 8 weeks. Twenty subjects consuming their habitual diets served as controls. Fasting blood samples were obtained 2 weeks prior to the study, at baseline, and at 2, 4 and 8 weeks. Intake of quercetin was assessed from 3 day food records collected at baseline and at 8 weeks. The serum quercetin concentrations were significantly higher in the subjects consuming berries compared to the control group  ANCOVA with repeated measures). During the berry consumption period the mean serum concentrations of quercetin ranged between 21.4 and 25.3 micro g/l in the berry group, which was 32-51% higher compared with the control group. According to 3 day food records, there was no difference in quercetin intake at baseline, but at 8 weeks the intake was 12.3 mg/day (mean+/-s.e.m.) in the berry group and 5.8 mg/day in the control group. The results indicate that the berries used in this study are a good source of bioavailable quercetin.

Quercetin and cancer growth
Several studies have shown that a group of antioxidant compounds found in grapes, green tea, soybeans and wine may lower the risk of a range of cancers, but exactly how these powerful compounds work has remained unclear. Now, researchers report that a plant-derived polyphenol can slow the growth of pancreatic cancer cells in mice and curb the spread of cells by triggering a series or reactions that causes the cells to self-destruct, a process known as apoptosis. The study is published in the April issue of the International Journal of Cancer. In humans, pancreatic cancer is a disease in which less than 1% of patients can expect to live for 5 years after diagnosis. Until the tumor grows large, there are no symptoms, and the cancer usually spreads to the lymph nodes, liver or lungs before it can be detected. In the study, the researchers investigated the effects of quercetin -a type of antioxidant polyphenol commonly found in apples--in mice given injections of human pancreatic cells. The mice used in the study are a specially bred strain that lacks an immune system, so that they quickly grow tumors when cancer cells are injected. The researchers also looked at how four different polyphenols interacted with rat pancreatic cancer cells in a laboratory culture dish. Quercetin caused apoptosis, decreased the growth of the main tumor and inhibited the spread of malignant cells, the researchers report. Mice treated with quercetin survived for about 75 days, compared with 67 days in mice not given the compound. Genistein, another type of polyphenol compound found in soy, also prevented the spread of cells and inhibited the growth of the primary tumor in mice while trans-resveratrol, found in wine and grapes, caused apoptosis in laboratory-grown cells, according to the report. The studies suggest that the "beneficial effects of quercetin and the other polyphenolic compounds were due to their ability to cause apoptosis," Dr. Michelle Mouria from the Veterans Affairs Greater Los Angeles Healthcare System and the University of California, Los Angeles, and colleagues conclude.

Quercetin supplement emails
Q. Do you know the effect of quercetin supplement on people with auto-immune disorders, in my case Sjogren's Syndrome? I cannot take echinacea products, for instance, but there are other substances which are not herbs which my doctor says are good for me. I have chronic sinus infections from my impaired immune system and the inability of my mucous membranes to stay moist enough to ward them off. What do you think would happen if I took quercetin supplements? I will ask my doctor after I get your opinion as I do not want to encourage any deterioration in our relationship, and she already thinks I am a bit edgy about some of this stuff. I am of the opinion, however, that I'd rather live five more years with a quality lifestyle rather than ten at the rather limited level I now have. I am 65 yrs. old with Sjogren's Syndrome and have been sick a good part of my life and am really very tired of being sick and tired.
   A. We are not aware of any research with quercetin and Sjogren's syndrome.

Q. It seems like the supplement sources for both Rutin and Quercetin are often from the Dimorphandra mollis plant. Rutin is a glycoside of Quercetin. Since I don't have a very extensive scientific background, is this saying that Rutin actually contains Quercetin (like Lactose is made up of galactose and glucose)? So would Rutin supplements (from Dimorphandra mollis extract) be a source of Quercetin? If so, what percentage of Rutin is Quercetin? Could a person take 500 mg of Rutin and in essence be taking a Quercetin supplement?
   A. Rutin is quercetin plus a glycoside. When rutin is ingested as a supplement, it is possible that the glycoside is cleaved and quercetin remains. However, we don't have a full understanding of what percentage of rutin is changed to quercetin in the body when a rutin supplement is taken. Since we have not seen any clinical trials regarding the effects of taking a rutin supplement versus a quercetin supplement, we don't know what clinical differences there would be between the two.

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