Activated Quercetin and Bromelain
Source Naturals
Activated
Quercetin with bromelain is a unique bioflavonoid derived product from plant sources. In human
cell culture studies, Quercetin has been shown to inhibit histamine
release. Additional research needs to be conducted to confirm the effects
of quercetin, if any, in humans. Bromelain is a pineapple enzyme. Magnesium ascorbate is a buffered
(non-acidic) form of vitamin C that helps support the immune system.
Click here to buy Quercetin supplement sale
Supplement Facts:
Vitamin C (as magnesium ascorbate)
Magnesium (as magnesium ascorbate)
Quercetin
Bromelain
Benefits of quercetin
Allergy - Quercetin may be useful for the treatment
of mast cell-derived allergic inflammatory diseases.
Cancer -- Quercetin has anti-tumor potential.
Heart disease -- Quercetin inhibits the proliferation and migration of aortic
smooth muscle cells, concomitant with inhibition of mitogen-activated protein kinase
phosphorylation. These findings provide new insights and a rationale for the potential use
of quercetin in the prophylaxis of cardiovascular diseases.
Prostate -- Quercetin my
inhibit the proliferation of androgen-independent human prostatic tumor cells.
Quercetin and bone
The effects of quercetin on bone minerals, biomechanical behavior, and structure
in streptozotocin-induced diabetic rats.
Cell Biochem Funct. 2007 Jan 31; Department of Histology-Embryology,
Faculty of Medicine, Trakya University, Edirne, Turkey.
This study was designed to investigate the effect of quercetin on bone minerals
and biomechanics in insulin-dependent diabetic rats. Diabetes was induced by 50
mg kg(-1) intraperitoneal streptozotocin (STZ) in a single dose. The rats were
randomly allotted into four experimental groups: A (control), B (non-diabetic +
quercetin ), C (diabetic), and D (diabetic + quercetin ) each containing 10
animals. The diabetic rats received quercetin (15 mg kg(-1) day(-1)) for 4 weeks
following 8 weeks of STZ injection. It was found that quercetin treatment
increased insulin, calcium, and magnesium levels. Three-point bending of the
femoral mid-diaphysis and necks showed significantly lower maximum load values (F(max))
in animals in the STZ group than the quercetin + STZ or control groups. The
results support the conclusion that quercetin treatment may decrease blood
glucose and increase plasma insulin, calcium, and magnesium. Quercetin treatment
may also be effective in bone mineral metabolism, biomechanical strength, and
bone structure in STZ-induced diabetic rats.
Cancer
Chemoprotective mechanism of the natural compounds,
epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and
cardiovascular diseases.
Curr Med Chem. 2009; Jagtap S, Meganathan K, Wagh V, Winkler J,
Hescheler J, Sachinidis A. Center of Physiology and Pathophysiology, University
of Cologne, Germany.
Cancer and cardiovascular disease (CVD) chemoprevention can be achieved by the
use of natural, synthetic, or biologic compounds to reverse, suppress, or
prevent the development of diseases. Chemoprevention is a potential anti-cancer
approach, which has reduced secondary effects in comparison to classical
prophylaxis. Natural compounds such as flavonoids reduce oxidative stress, which
is the most likely mechanism in the protective effects of these compounds. Even
though the exact mechanisms of action are not well understood another central
action mechanism of polyphenolic flavonoids seems to be an induction of
apoptosis as demonstrated in numerous cellular systems. Moreover, flavonoids may
modulate protein and lipid kinase signaling pathways. Understanding the
mechanism of these natural products will contribute to the development of more
specific preventive strategies against cancer and CVD. Much of the research in
the field is focused on epigallocatechin-3-O-gallate (EGCG), quercetin and
curcumin, which were found to have beneficial effects against cancer and CVD. We
review the chemoprotective mechanisms through which these natural compounds
exert their beneficial effects against cancer and CVDs.
Quercetin in onion and roasting
Thermal Degradation of Onion Quercetin Glucosides under Roasting
Conditions.
J Agric Food Chem. 2007 Jan 31; Department of Food Analysis, Institute
of Food Technology and Food Chemistry, Technical University of Berlin, Gustav
Meyer Allee 25, D-13355 Berlin, Germany.
In this study, the stability of selected model and onion
quercetin glycosides
under roasting conditions (180 degrees C) was determined. The influence of the
kind and position of the sugar moiety was investigated. As onions contain large
amounts of quercetin glycosides and are often subject to thermal processes in
food production, their major glycosides were isolated using counter current
chromatography and roasted. The thermal treatment led to a degradation of the
quercetin glycosides. The main product is the aglycone quercetin, which remained
stable during further roasting. During the roasting process of the quercetin
diglucoside isolated from onion, the formation of a monoglycoside as an
intermediate product was observed. This underlined that the stability of the
glycosides is dependent on the kind and position of the sugar moiety.
Quercetin on bisphenol A
The ameliorative effect of black tea extract and quercetin on bisphenol
A-induced cytotoxicity.
Acta Pol Pharm. 2009 Jan-Feb; Verma RJ, Sangai NP. Department of
Zoology, University School of Sciences, Gujarat University, Ahmedabad-380 009,
India.
The purpose of our study was, to explore the possible ameliorating
effects of black tea extract and quercetin, against bisphenol A-induced
cytotoxicity. For this, human red blood corpuscles (RBC) were taken as the
model. Blood samples collected in EDTA vials from healthy adults were used for
preparation of RBC suspension. This suspension was treated with bisphenol A with
and without black tea extract or quercetin. The results showed that addition of
bisphenol A causes concentration-dependent increase in rate of hemolysis.
Addition of black tea extract or quercetin alone to RBC suspension did not cause
any significant reduction. However, concurrent addition of bisphenol A and black
tea extract or quercetin caused concentration-dependent amelioration in
bisphenol A-induced cytotoxicity.
Quercetin Research Update
Consumption of black currants, lingonberries and bilberries increases
serum quercetin concentrations.
Erlund I, Marniemi J, Hakala P, Alfthan G, Meririnne E, Aro A.
Biomarker Laboratory, National Public Health Institute, Helsinki, Finland.
Eur J Clin Nutr. 2003 Jan;57(1):37-42.
To study serum quercetin concentrations of subjects consuming berries
or habitual Finnish diets. DESIGN: Randomized parallel dietary intervention.
Twenty subjects consumed
100 g/day of berries (black currants, lingonberries and bilberries) for 8 weeks.
Twenty subjects consuming their habitual diets served as controls. Fasting blood
samples were obtained 2 weeks prior to the study, at baseline, and at 2, 4 and 8
weeks. Intake of quercetin was assessed from 3 day food records collected at
baseline and at 8 weeks. The serum quercetin concentrations were
significantly higher in the subjects consuming berries compared to the control
group ANCOVA with repeated measures). During the berry consumption
period the mean serum concentrations of quercetin ranged between 21.4 and 25.3
micro g/l in the berry group, which was 32-51% higher compared with the control
group. According to 3 day food records, there was no difference in quercetin
intake at baseline, but at 8 weeks the intake was 12.3 mg/day (mean+/-s.e.m.)
in the berry group and 5.8 mg/day in the control group.
The results indicate that the berries used in this study are a good
source of bioavailable quercetin.
Quercetin and cancer growth
Several studies have shown that a group of antioxidant compounds found in
grapes, green tea, soybeans and wine may lower the risk of a range of cancers, but exactly
how these powerful compounds work has remained unclear. Now, researchers report that a plant-derived polyphenol can slow the growth of
pancreatic cancer cells in mice and curb the spread of cells by triggering a series or
reactions that causes the cells to self-destruct, a process known as apoptosis. The study
is published in the April issue of the International Journal of Cancer. In humans, pancreatic cancer is a disease in which less than 1% of patients can expect
to live for 5 years after diagnosis. Until the tumor grows large, there are no symptoms,
and the cancer usually spreads to the lymph nodes, liver or lungs before it can be
detected. In the study, the researchers investigated the effects of quercetin -a type of
antioxidant polyphenol commonly found in apples--in mice given injections of human
pancreatic cells. The mice used in the study are a specially bred strain that lacks an
immune system, so that they quickly grow tumors when cancer cells are injected. The researchers also looked at how four different polyphenols interacted with rat
pancreatic cancer cells in a laboratory culture dish. Quercetin caused apoptosis, decreased the growth of the main tumor and inhibited the
spread of malignant cells, the researchers report. Mice treated with quercetin survived
for about 75 days, compared with 67 days in mice not given the compound. Genistein, another type of polyphenol compound found in soy, also prevented the spread
of cells and inhibited the growth of the primary tumor in mice while trans-resveratrol,
found in wine and grapes, caused apoptosis in laboratory-grown cells, according to the
report. The studies suggest that the "beneficial effects of quercetin and the other
polyphenolic compounds were due to their ability to cause apoptosis," Dr. Michelle
Mouria from the Veterans Affairs Greater Los Angeles Healthcare System and the University
of California, Los Angeles, and colleagues conclude.
Quercetin supplement emails
Q. Do you know the effect of quercetin supplement on people with auto-immune
disorders, in my case Sjogren's Syndrome? I cannot take echinacea products, for
instance, but there are other substances which are not herbs which my doctor
says are good for me. I have chronic sinus infections from my impaired immune
system and the inability of my mucous membranes to stay moist enough to ward
them off. What do you think would happen if I took quercetin supplements? I will
ask my doctor after I get your opinion as I do not want to encourage any
deterioration in our relationship, and she already thinks I am a bit edgy about
some of this stuff. I am of the opinion, however, that I'd rather live five more
years with a quality lifestyle rather than ten at the rather limited level I now
have. I am 65 yrs. old with Sjogren's Syndrome and have been sick a good part of
my life and am really very tired of being sick and tired.
A. We are not aware of any research with quercetin and Sjogren's
syndrome.
Q. It seems like the supplement sources for both Rutin
and Quercetin are often from the Dimorphandra mollis plant. Rutin is a glycoside
of Quercetin. Since I don't have a very extensive scientific background, is this
saying that Rutin actually contains Quercetin (like Lactose is made up of
galactose and glucose)? So would Rutin supplements (from Dimorphandra mollis
extract) be a source of Quercetin? If so, what percentage of Rutin is Quercetin?
Could a person take 500 mg of Rutin and in essence be taking a Quercetin
supplement?
A. Rutin is quercetin plus a glycoside. When rutin is ingested as a
supplement, it is possible that the glycoside is cleaved and quercetin remains.
However, we don't have a full understanding of what percentage of rutin is
changed to quercetin in the body when a rutin supplement is taken. Since we have
not seen any clinical trials regarding the effects of taking a rutin supplement
versus a quercetin supplement, we don't know what clinical differences there
would be between the two.
Q. I am allergic to onions. Where can I find quercetin
that is not derived from onions?
A. Diallyl disulphide is the major allergen in garlic and onion,
rather than quercetin. It is not likely that quercetin supplements would have
any diallyl disulphide in them. If you are very concerned, you can ask the
makers of a particular quercetin supplement how they derive and produce their
product.
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Q. There was an article in the December 2008 issue of
the CSPI's Nutrition Action Healthletter regarding the effect of quercetin on
increasing the number of mitochondria. The article cited the research of Mark
Davis, director of the Psychoneuroimmunology of Exercise and Nutrition
Laboratory at the University of South Carolina in Columbia. A summary is given
here: "Davis's lab has found that seven days of quercetin supplementation in
mice increased endurance performance and helped build mitochondria, the
"powerhouses" of cells, which generate most of the adenosine triphosphate (ATP,
a key form of cellular energy) required by muscle tissue, the liver, and the
brain. Quercetin feeding also increased voluntary activity by about 40 percent
as measured with running wheels in the mouse cages. Davis says the heightened
exercise capacity is likely due to increased ATP production through synthesis of
more mitochondria. He also points to quercetin's stimulating effect on the
brain, caused by opposition of adenosine receptors (the same mechanism that
accounts for caffeine's stimulating effect)." Do you have any comments regarding
taking 3 capsules of Source Naturals Activated Quercetin per day?
A. We prefer not to rely on rodent studies since it is very
difficult to know what the ideal dosage would be in humans and whether the
benefits of usage would be counteracted by unknown side effects. Sometimes
revving up one's metabolism with certain supplements can place too much strain
on heart tissue or other organs. It is best to use supplements in moderation.
Tribulus terrestris
extract
for allergies