Pregnenolone side effects
Pregnenolone health benefit
Pregnenolone is a natural hormone that cannot be patented. Back in the
1940's, when researchers started experimenting with the use of pregnenolone, they realized
that it could be helpful for people under stress and it could increase energy in those who
were fatigued. However, about the same time, cortisol, another closely related hormone,
was discovered. Cortisol stole the limelight. When cortisol was given to individuals with
rheumatoid arthritis, there were outstanding short-term improvements. Photographs of these
remarkable recoveries were circulated and the medical community was impressed. Scientists
basically put pregnenolone aside to focus on cortisol. The structure of cortisol was
altered to make similar molecules such as dexamethasone and prednisone, much more powerful
steroids. Dexamethasone and other similar corticosteroids could be patented, and thus a
pharmaceutical company could make a lot of money by owning patents.
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Pregnenolone has stayed in relative obscurity since the 1940's, with only rare
mentions in the medical literature. A review of Medline, the computer system that records
all articles published in scientific journals, shows only a few studies published on
pregnenolone in recent years, and only a couple involve human subjects.
Benefits of pregnenolone
hormone
Some people find pregnenolone improves energy levels,
eyesight, memory, clarity of
thinking, wellbeing, and often sexual
enjoyment. Some women report lessening of hot flashes or premenstrual symptoms.
Studies in rodents show pregnenolone to be one of the most effective and powerful memory
boosters. Pregnenolone may increase levels of acetylcholine in the hippocampus and other
memory regions in the brain. However, pregnenolone is not risk-free.
Side effects of
Pregnenolone. These pregnenolone side effects can occur even on a low dosage of
3 to 5 mg taken over a few days or weeks.
Overstimulation and insomnia
Irritability, anger or anxiety
Acne, due to
the conversion of pregnenolone into androgens
Headaches
Possible scalp hair loss if used daily for prolonged periods
Irregularities of heart rhythm, palpitations on high doses
Unknown effects on the thyroid gland or other organs
Pregnenolone
danger
We're still in the early stages of learning about pregnenolone and its full
effects on the human body.
It is best to proceed with caution until more information is available. This means using
the lowest effective dose and seeking supervision by a knowledgeable health care provider.
There are some medical or psychiatric conditions where pregnenolone can be used
temporarily and then stopped. With this conservative approach, it is unlikely that any
problems would arise. Our major uncertainty at this time involves the long-term use of
pregnenolone as hormone replacement therapy, especially if high doses are used.
Pregnenolone can also cause heart palpitations in high doses.
With time, as more and more people use this hormone, we'll have a
fuller understanding of its benefits and side effects. Those who have already found pregnenolone to be helpful in terms of mood elevation, stress reduction, arthritis help,
visual and auditory enhancement, and so forth, but are concerned about unknown long-term
effects, may feel more comfortable using pregnenolone only as needed and frequently taking
time off from it. Taking these "hormone holidays" will mitigate any potential
unknown risks.
Daily use of pregnenolone over prolonged
periods should be no more than 1 to 3 mg unless you are closely followed by a health care
practitioner familiar with the clinical uses of this hormone. Current dosage available
over the counter, such as 25, 50, or 100 mg are TOO high. If you purchase a 10 mg pill or
capsule, take a portion of it if you plan to take it on a regular basis.
Is pregnenolone different that progesterone?
Pregnenolone is converted in the body to progesterone and these two hormones
have some overlapping similarities, but we still don't know exactly how their effects
overlap. Pregnenolone is also converted into DHEA, which, in turn may convert into
androstenedione, testosterone, and estrogens. The role of pregnenolone hormone
supplement use for
menopause
is a possibility that has not been studied adequately.
How is pregnenolone made?
There is a type of plant called a wild yam that is grown in certain parts of the
southern U.S. and in Mexico. This wild yam contains a compound called diosgenin that is
the precursor to steroid hormones. In a laboratory, diosgenin is converted into
pregnenolone. Further laboratory processing can convert pregnenolone into DHEA. The human
body does not have the ability (the required enzymes) to convert diosgenin (a six ring
structure) into pregnenolone (a four ring structure). Therefore, if you swallow pills that
are extracts of wild yams (diosgenin), you will not get pregnenolone or DHEA. The
conversion of diosgenin to pregnenolone has to be done in a laboratory. If you want
pregnenolone or DHEA, the bottles you buy must say that they contain actual pregnenolone
or DHEA, not extracts of wild yams or diosgenin.
What form of pregnenolone is best?
Oral
pregnenolone pills work well. Sublingual or micronized are also good options.
Can I take pregnenolone if I'm already on DHEA, estrogens, or
other hormones?
Since both DHEA and pregnenolone have some similar effects (however, they have
differences, too), you should lower your dose of DHEA when you go on pregnenolone. The
lowering of the dose should by the same amount as the pregnenolone dose. Before you add
pregnenolone, though, make sure you try it separately to see what kind of effects it has
on you, Once you know how you react to DHEA and pregnenolone separately, you can then
combine them. The amount of conversion of pregnenolone to estrogens is not fully
known.
Is it true that some people notice improvement in
vision while taking pregnenolone?
A good number of individuals
who have taken
pregnenolone have
reported enhancement of visual perception. Colors are brighter and clearer. Patterns are
more noticeable. Looking becomes more enjoyable. However, not everyone seems to be attuned
to this perceptual enhancement.
Pregnenolone studies
Chronic pregnenolone effects in normal
humans: attenuation of benzodiazepine-induced sedation.
Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM.
University of California, San Francisco School of Medicine, San Francisco, CA,
USA.
Psychoneuroendocrinology. 2004 May;29(4):486-500.
Pregnenolone is the major steroid precursor in humans. It is also a "neurosteroid"
and possesses intrinsic behavioral and brain effects in animals, affecting the
GABA(A) and other receptors. In two preliminary studies, we sought to
characterize its tolerability and psychotropic effects in humans. In Study 1, 17
normal volunteers received pregnenolone and placebo for 4 weeks each (15 mg PO
per day x2 weeks followed by 30 mg PO per day x2 weeks, vs. placebo x4 weeks) in
a within-subject, double-blind, cross-over design, with a 4 week drug-free
washout period separating the two arms. Subjects' behavioral responses were
assessed at the beginning and end of the 4-week pregnenolone arm and the 4-week
placebo arm. Pregnenolone was generally well-tolerated but, by itself, had no
significant effects on mood, memory, self-rated sleep quality or subjective
well-being. In Study 2, 11 subjects from Study 1 received a single dose of
diazepam (0.2 mg/kg PO) immediately following completion of Study 1 in order to
assess, in a between groups design, the impact of 4-weeks' pre-treatment with
pregnenolone (N=5) vs. placebo (N=6) on the acute sedative, amnestic and
anxiolytic effects of this benzodiazepine. Pregnenolone-pretreated subjects
showed significantly less sedation following diazepam (p<0.03); this effect was
clinically apparent. Diazepam's amnestic effects were non-significantly
attenuated, and ratings of anxiety were unaffected. These pilot data, based on
small samples, raise the possibility that chronically administered pregnenolone
antagonizes certain acute effects of benzodiazepines and may enhance arousal via
antagonist or inverse agonist actions at the benzodiazepine/GABA(A) receptor
complex. Further larger-scale studies, utilizing a broader range of doses and
experimental conditions, are warranted.
Pregnenolone
questions
Q.
Is Prenenolone a safe replacement for Prednisone, when Prednisone has been
contraindicated for a medical
condition?
A. Pregnenlone is not a substitute for prednisone,
they may have some overlapping effects but they also have quite different influences on
the body. Pregnenolone is much less understood than prednisone.
Q.
You may be interested in additional data backing up your cautions on your web
page. I had been taking 50 mgs of DHEA and pregnenolone each for about 9 months when I
went in for a routine physical exam. The exam turned up hyperthyroidism and atrial flutter
- neither of which had existed in any prior physicals. So, another profound 'thanks;' this
time for your internet article. With the information it contained, I was able to
alert my physician as to the probable cause of both conditions which was most
helpful in reaching an accurate diagnosis. Fortunately, with medication and 2 cardioversions, both conditions have now been eliminated. As you might guess, I've learned a lesson about
charging off on my own.
Q. Can you tell me if DHEA or pregnenolone will develop
"unwanted feminine character in men". And if it is so, can my body undo the
effect if I stop taking them.
A. They may cause both masculine (ie hair loss on the scalp) and
perhaps feminine (breast tissue) depending on how you metabolize and how much
you take, and most of the time the effects reverse with time.
Q. I have been taking
pregnenolone
for 7 years now. I started when I began menopause and had terrible hot flashes.
At that point I would have to take up to 180 mg. at a time to totally get rid of
the hot flashes. It also gave me a great sense of well being and energy. I
continued on that pregnenolone dosage for about 3 months, on a daily basis, and
then
reduced it to 50 mg a day and was still free from hot flashes and all other
menopausal symptoms. I continued to take 50 mg daily of pregnenolone,
occasionally taking a break off a few weeks here and there, or a few days off
and on, but basically have been taking pregnenolone 50 mg on an almost daily
basis for 7 years. I have never had any pregnenolone side effects. No
palpitations. My hair has thinned a bit, but I don't know if that would have
happened anyway from age. What I am wondering, is if I can give pregnenolone to
my 8 yr old female dog who is not fixed and
still goes into heat. It seems that each time she comes out of heat, she has a
few weeks afterwards where her hormones are a bit out of control and she goes
into false pregnancy. The vet wants me to get her spade, but before I do that, I
thought pregnenolone might help her, the same way it helped me. The vet doesn't
know anything about it.
Also, I was under the impression that pregnenolone is not retained in the
tissues and that excess unneeded amounts are excreted. My gynecologist told me
pregnenolone is safe in so much as that it is not retained in the liver tissue.
Would this be true for the rest of the body as well?
A. We think taking this high dosage of pregnenolone for so long is
a gamble and the long term effects a few more years from now are not known,
including the potential risk for cancer. Keep us updated. As to using
pregnenolone in a dog, this is outside of our range of knowledge since we don't
deal with animals. With most hormones in most people, taking the least amount
that works is often the best option.
Q. I'm a 30yr old male and about 3
years ago I was diagnosed with advanced Hypogonadotropic Hypogonadism, my body
produces very very little (pretty much zero) testosterone on its own. Because of
it I lost about 30Lbs. of muscle, lacked my sexual ability and felt severaly
depressed. I've been doctoring at the Mayo Clinic for this problem. At first
they thought it was because of a visectomy I had 4 months previous to the
syptoms I started having, then they thought it may have been a pituatary
disfunction. Their final diagnosis is the Hypogonadism. They figured it could
have been from short term, low dosage deca treatments I had taken for a shoulder
injury. The Deca was only taken for that reason in low dosages and never abused.
After the diagnosis they tried Test-Gel and my body didn't absorb it very well.
They decided to start me on intramuscular injections of 200mg/ml testosterone
enanthate. Iv'e been on the injections for about 2.5 years and it's a pain. My
levels are never constant and we have switched my dosage about a dozen times
because the high and low counts are always changing and or never right. I've
grown hair on my chest and abs, my hair is thicker on my legs and I'm seeing
some starting on my shoulders and back. Besides the hair, my back is always
broke out in acne. I feel better after being on the shots, but sometimes I get
real emotional, I still can't gain back the muscle or weight I once had and
these side side affects are really affecting my self esteem. Lately, a
friend of mine suggested I start taking pregnenolone. He said it would control
the testosterone I was taking from aromatizing into estrogen so that my levels
would be more constant. I already hate taking just the testosterone because of
all the side affects, you know like tumors, cancer, etc.
A. We cannot offer individual advice just to say that adding
pregnenolone could increase hormonal side effects.
Q. I just a bottle of
pregnenolone
10 mg and MULTI-VIT Rx. The warnings on the pregnenolone suggest extreme
caution. My doctor advised that my recent low energies are due to an alarming
testosterone count of 236. I am 57, male, 5' 9", 160lbs., and have always been
in good health, but I have the symptoms of those low testosterone numbers. I
also have had years of high ldl and an hdl of about 39 or 40, for which I've
been dieting exercising, taking 4000mg Fish Oil daily, 150mg COQ10, 10 mg
Policosanols, and Cinnamon supplements. I'm also taking 1/4 of a 3mg Melatonin
pill nightly for the past week, with good results for my insomnia, and I take
Glucosamine Chondroitin to aid my daily exercised joints and my touch of
Sciatica. Having read so many good reviews on pregnenolone, I now want to try at
least 1 pill a day. In your estimation, would this pregnenolone dosage be safe
or unsafe? I also take 25mg DHEA every other day.
A. We can't give individual advice on what supplements to take or
in what combinations, but just to say hormones are dangerous when misused and
when pregnenolone is added to DHEA, the effects are additive, and cumulative.
Q. I have read a site by Ray
Sahelian, M.D. on the safety doses and side effects of pregnenolone. I was
taking 25mg. and was very overstimulated to the point of feeling fearful. So I
cut it down. Im using 15 mg. now still hyper. But I just read an website Called
Health World written by Dr. Ray Sahelian and he talks about taking larger doses,
25, 50 mg. I am in menopause and can't tolerate progesterone, all my hormones is
low how will my body decide what hormones to make first? I really need
progesterone so I can use estrogen supplement.
A. The field of hormone use is very complicated and there is no
agreement in the medical community on which hormones to use in which form, in
which dosages, and for how long. As a general rule, men and women should use the
least amount that works for them and to take frequent breaks from use if
possible. Any more details have to dealt with on an individual basis with
consultation of a personal physician. The
article you refer to was written many years ago. After further experience, Dr.
Ray Sahelian has realized that DHEA and pregnenolone hormones are much more
potent than he first understood them to be, and hence he has revised his dosages
much much lower.
Q. About two months ago, I began taking
Pregnenolone (1 mg/day...I am VERY sensitive!), and have noticed many
benefits. I recently learned that pregnenolone can help with memory. I have not
noticed that particular effect, and, given that I am recovering from a brain
injury, as you can imagine, a better memory is very important to me. I was
wondering if you would be interested in obtaining/using my "clinical"
experience, using Pregnenolone, from the perspective of a "patient" with a brain
injury, and its effects on memory, specifically. I would be willing to follow
some "protocol" or regimen (which would actually be challenging for me given my
executive functioning impairments), if that would be of interest to you and your
research. I just wanted to contact you and offer my "experience" with
Pregnenolone (which so far has been brief), from a patient with a head injury. I
was thinking that Pregnenolone helps
with the "synapses" in the brain).
A. At this time we don't have a specific protocol or questionnaires
or research oriented forms regarding supplement use. Our focus is more on the
clinical and experiential aspect. 1 mg of pregnenolone may not provide a
noticeable influence on memory. Higher dosages may provide such memory benefits
but then the side effects would not be appreciated. Can you tell us what benefit
you have noticed on 1 mg of pregnenolone?
Q. Feedback from me regarding any
benefits I do derive from the Pregnenolone. As I am recovering from a head
injury,
I don't know if that "changes" the types of benefits that I am getting from
Pregnenolone or not. What I can do, however, is tell you what I have experienced
from Pregnenolone. I am 47 years old and sustained a head injury (due to
whiplash) on September, 27, 2002. I have been to many doctors to try and "get
better"...well, as you know, it is a long, slow recovery from a head injury (it
turns out, this was my second head injury...my first was 13 years prior...which
makes this one exponentially worse). I believe very firmly in healing through
holistic and natural methods (and, it turns out, following the injury, I became
"extremely sensitive" to almost everything, including medicines...food,
environmental, chemical, etc....most of the "reactions" caused me great head
pain (in varying "locations" in my head)).
I am unable to take any medicines, which is fine with me...about the only thing
I take on a intermittent basis is Vicodin (1/2 doses) and Claritin-D (1/2
doses). The two main "treatments" which I obtained that were the biggest help to
me
was going to a "neurofeedback" clinic in Arizona for two months (exclusively).
Three times a week, I received treatment which included electrodes attached to
my head (to stimulate specific areas of the brain), I listened to "filtered"
classical music (again, which help to regenerate parts of the brain), and
performed exercises (i.e., number counting, and using your mind to "guide" a
Pac-man-like character on a screen...like biofeedback). I was MUCH better after
the two months (I would have liked to stay longer for more treatment, but it was
very expensive...now, some of
their protocols are available in "home version" which I am planning to purchase
and use). I feel that if I hadn't had that treatment, I wouldn't have been able
to go back to work...at my old job. Long-term, I ultimately had to have a "less
responsible" job created for me at work, because, in my old job, I was
responsible for a lot of money for the company, and I was beginning to make
mistakes, and had much trouble with executive functioning in a busy job. Now I
am doing "special projects"...which is hard on my ego, but better for my brain.
Well, the other treatment which really helped all the head pain and
sensitivities is called, "N.A.E.T"...it's basically "allergy elimination
techniques". It is treating all the "meridians" around the spine, while holding
a sample of the "allergen" and then going through a period of "time" to
"re-program" the body to not react to the allergen. It has helped me quite a
bit, physically, to not be in as much pain. (plus, I can eat a bit more variety
in foods now). So, then I was in "plateau" mode with regard to recovery, but I
was still
having problems at work...mainly with a lack of energy, concentration,
attention, and memory. A few months ago, I took the
Mind-Power-Rx for a couple months, and noticed a big difference in my energy
level and ability to concentrate... even my boss noticed my increase in
"productivity". Then, I forgot (!) to reorder Mind Power for several months (I
just started taking it again two days ago, and I have already noticed the
difference at work again! This is 1/2 doses). About two months ago, I ordered
the Pregnenolone (not knowing that it wasn't big on increasing libido, I was
hoping it would help my almost non-existent, sex drive)...I tried DHEA before,
and had lots of problems with "side affects"...mainly heart palpitations and
irritability. So, I knew about the hormone "cascade" factor and decided to try
Pregnenolone, being that it was "higher" on the cascade. (I also have had issues
with pre-menopause and thought it might help with that area, too). I am probably
one of the THE most "sensitive" people, that is why I began with 1 mg of
Pregnenolone a day. Even with that small dosage, this is what I noticed: -
Tremendous feeling of well-being (just being in a "good mood"!...with a head
injury, "one" tends to be constantly in a state of dullness, or mild depression)
- Ability to work "through" my daily physical discomfort because my mood is so
much better, and my ENERGY level is much better! - Now, I have read that
Pregnenolone is not known for increasing libido, but mine went through the roof!
Really, I became a sex maniac! (now, you have to understand that I have always
been very, very low on libido...something
that I think has been for emotional childhood reasons, and possibly
hormone-wise, due to my pre-menopause age.) I am truly enjoying sex for the
first time in my life...I finally "get" what everyone has been talking about! It
sounds dramatic, I know, but all I know is that it was coincident with taking
Pregnenolone (again, maybe my head injury "pre-disposition" has something to do
with the reactions I am getting from Pregnenolone). - Oh, yes!...visual and
auditory senses have increased greatly! (I know Dr. Ray Sahelian has experienced
this, too...I am very kinesthetic so I think I
notice things regarding the senses more easily and quickly than others)! I am
sitting here right now, and I keep taking breaks from typing this response....to
slide over and deeply "inhale" the wonderfully fragrant scent coming from the
dozen red roses my hubby just gave me for Valentine's Day! That is unlike
me...to sit and sniff flowers! Additionally, my ears have been bad since the
head injury...it feels like my ears are filled with mud most of the time...sound
is very muffled for me. So, when I was recently listening to music (post
pregenenolone !)...I was in my car, listening to some kind of music...and, I
kept looking around at the cars around me, outside...because I kept hearing
"someone else's music playing"...then, after remembering that Dr. Ray Sahelian
had commented about hearing more acutely on Pregnenolone, I turned off my own
music, and the "other music" stopped! I couldn't believe it...but I am finally
hearing MORE of the subtle harmonies and background melodies in my music...that
is literally music to my ears, because I really love music! I am still getting
used to it, though, because it still sounds "outside" of my own music, to me. -
As for my memory, I seem to notice that the Mind Power is helping more in that
area than the Pregnenolone ...which is interesting (on the Pregnenolone side of
things)...as you suggested, I may not be taking enough Pregnenolone to gain the
better memory benefits, but I am content right now at this dosage, and the Mind
Power is helping. All I can say is that my memory is better due to the Mind
Power, and for that I am totally thrilled! Well, that is all I can remember
(ha!) regarding the Pregnenolone benefits, but this is PLENTY for me right now!
If I felt much better, I don't think I could handle it! LOL! I am a
devoted fan of Dr. Ray Sahelian, and I am always telling others about his
amazing products!
Q. Can there be side-effects with
abruptly stopping a 100 mg a day dosage of pregnenolone?
A. It's possible side effects could occur with abrupt stopping, it
depends on a person's medical condition, other supplements used, other medicines
or hormones used, and length of time of pregnenolone use. A gradual decline in
pregnenolone dosage may be an option.
Q. i would like to get some advise
related to pregnenolone and DHEA. I'm a 48 years old female with some medical
issues ( acid reflux, asthma, ovarian cyst, adrenal adenoma ), i started a
program on mineral supplements and pregnenolone ( 25 mgs /5 times x week / 2
months), and DHEA ( 10 mgs /5 times a week/ 2 months) i was under the
supervision of an holistic MD. Two months after the treatment i started having
anxiety, panic attacks and insomnia ( i also was seeing a chiropractor for an
old neck injury), i stopped the supplements as well as the hormones, according
to the lab results my pregnenolone levels went from less then 10 to 30 in two
months, my doctor prescribed Xanax to help with sleep, two more months went by
and i still have insomnia, i only take the xanax twice a week to control my
anxiety or force myself to sleep , also since two months ago i'm dealing with
terrible dryiness in my mucosa ( eyes, nose, mouth). Is there a possibility that
pregnenolone can be causing these issues? i tried melatonin for insomnia,
however it is not working.
A. We have had no reports yet of pregnenolone or DHEA influencing
mucosa in terms of dryness but it is possible. These hormones are potent and can
cause side effects. You may with to see suggestions for
sleep here.
Q. I was reading what you had to say
about pregnenolone on the Internet. My question to you is about "hormone
holidays". You mentioned in your information page; after taking pregnenolone
2mgms a day for five days take a hormonal holiday . How long do you recommend?
Is 5 days on and then 2 days off a good plan ? I am currently taking 5 mgms
sublingual and would like to take a "holiday".
A. Each person is different in the dose of pregnenolone that they
need and how often. Most people do not need to take it at all. We can't be any
more specific, there are too many variables involved in taking supplements and
hormones.
Q. It is 3 am in the morning & I am
researching sex boosting properties through a book called Natural Sex Boosters
bt Ray Sahelian, MD. I am looking at three supplements: Pregnrnolone - DHEA -
Androstenedione. From the research I have encountered, I am lead to believe that
Pregnenolone is at the top of the chart which converts into DHEA, which then
converts into Androstenedione and again in turn, the body converts into
Testosterone. My goal at the end of all this is to maintain an equal amount of
these hormones flowing throughout my body. All the hormones I have mentioned
here have one sex boosting property (which I am after) in common & that is
heightened skin & genital sensation. This is the where I am lost: According to
the research, is Pregnenolone the only supplement one needs in order to have all
the above hormones in the body? Or does one need to take all three to maintain
this? & if so, can they be taken together? I am concerned as inappropriate use
can lead to unwanted results. If you could kindly elaborate on this for me I
would be most grateful.
A. Pregnenolone is able to convert into all the hormones you
mention. It is impossible to predict which of these hormones, or the
combinations would be beneficial to take, and in what dosages. These are
powerful hormones and should be used with caution and only occasionally.
Androstenedione is no longer available over the counter. One option is to try
pregnenolone for a few days, take a break for a week, and then try DHEA for a
few days to see which one works for you best in increasing genital sensation.
There are sexual herbs that also help with sensation, such as tongkat ali or
LJ100. Passion Rx has tongkat ali and it also helps with sensation. All of these
hormones and herbs are potent and should only be used a few days a week.
Q. Does pregnenolone hormone help with
natural male enhancement?
A. Pregnenolone use can enhance sexual drive after a few days, but
this hormone does not have as much of an effect on erectile function as some
aphrodisiac herbs such as tribulus terrestris or a combination such as Passion
Rx.
Q. I appreciate both the thoroughness and
the caution of your website. I'd like to ask you if you recommend pregnenolone
for people (in their sixties) with low DHEA. Are low doses of hormones like
pregnenolone and DHEA good or bad or in between for people with heart disease?
A. Hormone supplements such as DHEA and pregnenolone should only be
used if there is significant deficiency in these hormones that are leading to
clinical symptoms. When taken as supplements, only low dosages should be used.
Each person is unique and we don't make wide ranging generalizations that all
people over 60 should or should not take these hormones. It is a case by case
evaluation.
Q. If someone has adequate serum levels
of DHEA does that mean that pregnenolone is not needed since the DHEA is in a
sufficient range. Can one have adequate DHEA and still need pregnenolone? Which
is the best way to test the pregnenolone levels-saliva or serum?
A. The term adrenal fatigue is not a helpful term for diagnosis or
treatment. We prefer treating and evaluating the whole person and the symptoms a
person has rather than overly focusing on levels of hormones or blood studies.
If adequate DHEA levels are present, then it is likely that adequate levels of
pregnenolone are also present. Blood levels of pregnenolone are more consistent
and easier to interpret than saliva levels.
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