Enzymatic Therapy -
Petadolex, 60 Softgels
Petadolex contains the patented extract of butterbur that supports healthy
blood vessel tone in the brain, as well as normal blood flow in the
brain.* It has been the subject of two placebo-controlled clinical
studies. In the most recent, participants reported a 62% improvement."
Petadolex is standardized to contain 15% of butterbur's key ingredient, petasin. It's also guaranteed to be pyrrolizidine alkaloid (PA) free, so you can use it with confidence. PA's are toxic compounds that can harm the liver. Studies demonstrate patented Petadolex is safe and well tolerated.
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Active ingredients in Petasites
Petasin, a kind of sesquiterpene ester, appears to be a major active compound of
petasites hybridus extract. It has inhibitory activities on leukotriene generation in
eosinophils and neutrophils. This indicates that it may have anti-inflammatory and
anti-allergy properties. Petasites may be helpful for seasonal allergic rhinitis.
Petasites also helps reduce smooth muscle spasm.
Medical uses for Petasites
Migraine Headache: Two clinical studies using 50 mg and 75 mg of a standardized
Petasites extract twice daily for 12 weeks demonstrated its effectiveness as a
prophylactic treatment for migraine headaches. When used to treat migraines, administration is
prophylactic and supplementation should be carried out daily for a few weeks and then
tapered until migraine incidence begins to increase. Petasites may work by preventing
peptidoleukotriene biosynthesis.
Feverfew
herb is promoted for headache relief, so is
butterbur herb.
Effectiveness of Petasites hybridus preparations
in the prophylaxis of migraine: a systematic review.
Phytomedicine. 2006 Nov;13(9-10):743-6. Headache Center Hirslanden,
Münchhaldenstr. 33, 8008 Zürich, Switzerland.
The objective of this review was to evaluate the strength of evidence of
effectiveness for Petasites hybridus in the prophylaxis of migraine. Several
databases and other sources were searched to identify randomised-controlled
trials investigating Petasites hybridus preparations. Two trials totalling 293
patients (60 and 233 patients) were included in this review. Both trials
investigated the proprietary Petasites root extract Petadolex. The extract at
higher dose (150 mg) showed a greater decreased frequency of migraine attacks
and a greater number of responders (improvement>50%) after treatment over 3-4
months than the extract at lower dose (100 mg) and placebo. Moderate evidence of
effectiveness is, thus, available for a higher than the recommended dose of the
proprietary Petasites root extract Petadolex in the prophylaxis of migraine.
Further rigorous studies are required to confirm effectiveness and safety in
long-term use before treatment with Petasites root extract can be recommended as
an alternative option in the treatment schedule for the prophylaxis of migraine.
Petasites hybridus (Butterbur root) extract in the treatment of asthma - an open
trial.
Altern Med Rev. 2004 Mar;9(1):54-62.
Danesch UC.
University of Heidelberg, Germany; past research position, Stanford School of
Medicine; Research and development, Weber and Weber. Correspondence address:
Muenchner Strasse 13, D-82061, Neuried, Germany.
The efficacy and tolerability of a butterbur root extract (Petadolex) for the
treatment of asthma was analyzed in a prospective, non-randomized, open trial.
Subjects included 64 adults and 16 children/adolescents treated for two months
with the extract, followed by two months during which the intake of the extract
was optional. Concomitant asthma medication was permitted. The number, duration,
and severity of asthma attacks decreased, while peak flow, forced expiratory
volume (FEV1), and all measured symptoms improved during therapy. In addition,
more than 40 percent of patients using asthma medications at baseline reduced
intake of these medications by the end of the study. This study suggests the
Petasites hybridus extract Petadolex is an effective and safe therapy for the
treatment of asthma.
Gastrointestinal Disorders
A German study found extracts of
Petasites blocked ethanol-induced gastric damage and reduced ulcerations of the small
intestine caused by indomethacin, an anti-inflammatory drug used to treat arthritic
conditions. The results of this study were attributed to inhibition of lipoxygenase
activity and leukotriene biosynthesis.
Petasites Safety
Petasites has not been studied extensively enough to determine its side effects.
Petasites Dosage
Typically, petasites extracts are standardized to contain a minimum of 7.5 mg of
petasin and isopetasin. The adult dosage ranges from 50-100 mg twice daily with meals.
Enzymatic Therapy -
Petadolex, 60 Softgels
Petadolex is standardized to contain 15% of butterbur's key ingredient, petasin. It's also guaranteed to be pyrrolizidine alkaloid (PA) free, so you can use it with confidence. PA's are toxic compounds that can harm the liver. Studies demonstrate patented Petadolex is safe and well tolerated.
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