Enzymatic Therapy -
Petadolex, 60 Softgels

Petadolex contains the patented extract of butterbur that supports healthy
blood vessel tone in the brain, as well as normal blood flow in the
brain.* It has been the subject of two placebo-controlled clinical
studies. In the most recent, participants reported a 62% improvement."
Petadolex is standardized to contain 15% of butterbur's key ingredient, petasin. It's also guaranteed to be pyrrolizidine alkaloid (PA) free, so you can use it with confidence. PA's are toxic compounds that can harm the liver. Studies demonstrate patented Petadolex is safe and well tolerated.
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Active ingredients in Petasites
Petasin, a kind of sesquiterpene ester, appears to be a major active compound of
petasites hybridus extract. It has inhibitory activities on leukotriene generation in
eosinophils and neutrophils. This indicates that it may have anti-inflammatory and
anti-allergy properties. Petasites may be helpful for seasonal allergic rhinitis.
Petasites also helps reduce smooth muscle spasm.
Medical uses for Petasites
Migraine Headache: Two clinical studies using 50 mg and 75 mg of a standardized
Petasites extract twice daily for 12 weeks demonstrated its effectiveness as a
prophylactic treatment for migraine
headaches. When used to treat migraines, administration is
prophylactic and supplementation should be carried out daily for a few weeks and then
tapered until migraine incidence begins to increase. Petasites may work by preventing
peptidoleukotriene biosynthesis.
Effectiveness of Petasites hybridus preparations
in the prophylaxis of migraine: a systematic review.
Phytomedicine. 2006 Nov;13(9-10):743-6. Headache Center Hirslanden,
Münchhaldenstr. 33, 8008 Zürich, Switzerland.
The objective of this review was to evaluate the strength of evidence of
effectiveness for Petasites hybridus in the prophylaxis of migraine. Several
databases and other sources were searched to identify randomised-controlled
trials investigating Petasites hybridus preparations. Two trials totalling 293
patients (60 and 233 patients) were included in this review. Both trials
investigated the proprietary Petasites root extract Petadolex. The extract at
higher dose (150 mg) showed a greater decreased frequency of migraine attacks
and a greater number of responders (improvement>50%) after treatment over 3-4
months than the extract at lower dose (100 mg) and placebo. Moderate evidence of
effectiveness is, thus, available for a higher than the recommended dose of the
proprietary Petasites root extract Petadolex in the prophylaxis of migraine.
Further rigorous studies are required to confirm effectiveness and safety in
long-term use before treatment with Petasites root extract can be recommended as
an alternative option in the treatment schedule for the prophylaxis of migraine.
Petasites Safety
Petasites has not been studied extensively enough to determine its side effects.
Petasites Dosage
Typically, petasites extracts are standardized to contain a minimum of 7.5 mg of
petasin and isopetasin. The adult dosage ranges from 50-100 mg twice daily with meals.
Enzymatic Therapy -
Petadolex, 60 Softgels
Petadolex is standardized to contain 15% of butterbur's key ingredient, petasin. It's also guaranteed to be pyrrolizidine alkaloid (PA) free, so you can use it with confidence. PA's are toxic compounds that can harm the liver. Studies demonstrate patented Petadolex is safe and well tolerated.
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