Buy Milk Thistle liver supplement
Buy Milk thistle - milk thistle dosage for liver

Milk thistle is commonly found growing wild in a variety of settings, including roadsides. The seeds of the dried flower are used. Milk thistle's active ingredient is a flavonoid called silymarin, an antioxidant said to protect liver cells from toxins. Sylimarin apparently promotes liver cell protein synthesis and decreases the oxidation of glutathione.
     Milk thistle or silymarin may potentially be beneficial in a number of diseases involving the liver. The dose of silymarin used in studies has ranged from 200 to 800 mg per day.

Milk Thistle supplement extract  80% Silymarin

Milk Thistle supplement extract is standardized to 80% silymarin, the key constituent that exerts a protective effect against substances potentially harmful to the liver.


Milk Thistle Supplement Facts:
Milk thistle extract -  200 mg         
   (seed) standardized to 80% Silymarin

Recommendation: Take 1 milk thistle capsule daily or as recommended by your health care provider. Milk thistle dosage varies regarding your medical condition.

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Milk thistle benefit
Milk thistle herbal extracts have been used as traditional herbal remedies for 2000 years. Milk thistle supplements are widely used to protect the liver against toxins and to control chronic liver diseases. Research shows milk thistle supplements have benefits in terms of cancer, diabetes, and heart disease.

Active compounds in milk thistle
Six main active constituents in milk thistle include silydianin, silychristin, silyamandin, diastereomers of silybin (silybin A and B) and diastereomers of isosilybin (isosilybin A and B) in silymarin.

Milk Thistle Research Update
Silymarin extraction from milk thistle using hot water.
Duan L, Carrier DJ, Clausen EC. University of Arkansas, 3202 Bell Engineering Center, Fayetteville, AR 72701.
Appl Biochem Biotechnol. 2004 Feb;114(1-3):559-68.
Hot water is attracting attention as an extraction solvent in the recovery of compounds from plant material as the search for milder and "greener" solvents intensifies. The use of hot water as an extraction solvent for milk thistle at temperatures above 100 degrees C was explored. The maximum extraction yield of each of the silymarin compounds and taxifolin did not increase with temperature, most likely because significant compound degradation occurred. However, the time required for the yields of the compounds to reach their maxima was reduced from 200 to 55 min when the extraction temperature was increased from 100 to 140 degrees C. Severe degradation of unprotected (plant matrix not present) silymarin compounds was observed and first-order degradation kinetics were obtained at 140 degrees C.

Milk thistle and cirrhosis of liver
Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver.
Hepatol. 1989 Jul;9(1):105-13. Ferenci P. niversity of Vienna, Austria.
Silymarin, the active principle of the milk thistle Silybum marianum, protects experimental animals against various hepatotoxic substances. To determine the effect of silymarin on the outcome of patients with cirrhosis, a double blind, prospective, randomized study was performed in 170 patients with cirrhosis. 87 patients (alcoholic 46, non-alcoholic 41; 61 male, 26 female; Child A, 47; B, 37; C, 3; mean age 57) received 140 mg silymarin three times daily. 83 patients (alcoholic 45, non-alcoholic 38; 62 male, 21 female; Child A, 42; B, 32; C, 9: mean age 58) received a placebo. Non-compliant patients and patients who failed to come to a control were considered as 'drop outs' and were withdrawn from the study. All patients received the same treatment until the last patient entered had finished 2-years of treatment. The mean observation period was 41 months. There were 10 drop outs in the placebo group and 14 in the treatment group. In the placebo group, 37 (+2 drop outs) patients had died, and in 31 of these, death was related to liver disease. In the treatment group, 24 (+4 drop outs) had died, and in 18 of these, death was related to liver disease. The 4-year survival rate was 58 +/- 9% in silymarin-treated patients and 39 +/- 9% in the placebo group. Analysis of subgroups indicated that treatment was effective in patients with alcoholic cirrhosis and in patients initially rated 'Child A'. No side effects of drug treatment were observed.

Milk thistle supplement questions
Q. Is it okay to take a milk thistle supplement along with Bioperine supplement or a resveratrol supplement?
   A. Much depends on the dosages, but if the dosages are low, milk thistle herb can be taken together with the others, but first try each one by itself for a week.

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