60 Softgel Capsules
Lyprinol is a unique, stabilized marine lipid extract to provide nutritional
support for healthy joint function.• Stabilized marine lipid extract for joint support
Lyprinol Supplement
Lyprinol
supplement for arthritis mussel extract information for asthma
The New Zealand green-lipped mussel (Perna canaliculus) is the source of an
extract with a product name of
Lyprinol. Claims have
been made that the preparation may be helpful in the management of inflammatory
diseases. Results of clinical studies to date have been contradictory, but there
is some evidence that mussel extracts have some anti-inflammatory capabilities,
and may potentially be helpful in asthma and arthritis.
Lyprinol supplement 50 mg
60 Softgel Capsules
Lyprinol is a unique, stabilized marine lipid extract to provide nutritional
support for healthy joint function.
• Stabilized marine lipid extract for joint support
Lyprinol Supplement
What the research says
about Lyprinol
Lyprinol and arthritis benefit
A lipid-rich
extract, prepared by supercritical fluid (CO2) extraction of freeze-dried stabilized NZ
green-lipped mussel powder (Lyprinol) has shown significant anti-inflammatory (AI)
activity when given to animals and humans. When treated p.o. with Lyprinol, Wistar and
Dark Agouti rats developed neither adjuvant-induced polyarthritis or collagen(II)-induced
auto-allergic
arthritis. This was achieved with doses < NSAIDs, and 200 times < of
other seed or fish oils. Lyprinol subfractions inhibited LTB4 biosynthesis by PMN in
vitro, and PGE2 production by activated macrophages. Much of this AI activity was
associated with omega-3 PUFAs and natural antioxidants [e.g. carotenoids]. In contrast to
NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does
not affect platelet aggregation [human, rat]. Clinical studies, either controlled or
randomized, have demonstrated very significant AI activity in patients with osteoarthritis
(OA), rheumatoid arthritis, asthma, and other inflammatory conditions. Lyprinol is a
reproducible, stable source of bioactive lipids with much greater potency than
plant/marine oils currently used as nutritional supplements to ameliorate signs of
inflammation.
Q. If a person takes Lyprinol, is it necessary to
continue taking omega 3 fish oil pills? Would there be any harm in taking both?
A. We don't foresee any untoward reactions between reasonable
dosages of Lyprinol and omega 3 fish oil pills, but the decision on which
supplements to take and in what combination rests with the consumer and their
doctor.
Asthma and Lyprinol
Asthma
is a
chronic inflammatory disease of the airways mediated, at least in part, by leukotrienes
and other lipid mediators. Experimental studies have shown that the lipid extract of New
Zealand green-lipped mussel, Perna canaliculus, is effective in inhibiting 5'-lipoxygenase
and cyclo-oxygenase pathways responsible for production of eicosanoids, including
leukotrienes and prostaglandins. The aim of this study was to assess its effect on
symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H2O2) in expired
breath condensate as a marker of airway inflammation in patients with
steroid-naive asthma. Forty six patients with asthma received two capsules of Lyprinol or placebo b.i.d for 8 weeks. Each
capsule of Lyrinol contained 50 mg omega-3 polyunsaturated fatty acids and 100 mg
olive oil, whereas placebo capsules contained only 150 mg olive oil. There was a
significant decrease in daytime wheeze, the concentration of exhaled H2O2 and an increase
in morning PEF in the Lyprinol group compared to the placebo group. There were no
significant side-effects. The authors conclude that Lyprinol, the lipid extract of New Zealand
green-lipped mussel may have some beneficial effect in patients with atopic asthma.
Lyprinol and intestinal mucositis
Lyprinol only partially improves indicators of small intestinal integrity in a
rat model of 5-fluorouracil-induced mucositis.
Cancer Biol Ther. 2007 Nov. Centre for Paediatric and Adolescent
Gastroenterology, Children, Youth and Women's Health Service and Discipline of
Physiology, School of Molecular and Biomedical Science, School of Agriculture,
Food and Wine, University of Adelaide, South Australia, Adelaide, Australia.
Intestinal mucositis is a common and debilitating side-effect of chemotherapy,
associated with severe small intestinal inflammation. Marine oils, such as
Lyprinol, a lipid extract derived from New Zealand Green-lipped Mussels, rich in
long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA), have demonstrated
therapeutic potential for the treatment of inflammatory conditions. We assessed
the effects of Lyprinol on the severity of 5-fluorouracil (5-FU)-induced
mucositis in female Dark Agouti rats. Lyprinol treatment in rats with
5-FU-induced mucositis only minimally decreased indicators of intestinal
integrity.
Lyprinol Research Update
Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand
green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the
hip and knee: a multicenter 2-month clinical trial.
Cho SH, Jung YB, Seong SC, Park HB, Byun KY, Lee DC, Song EK, Son JH.
Yonsei Medical Clinic, Seoul, Korea.
Allerg Immunol (Paris). 2003 Jun;35(6):212-6.
To validate the clinical efficacy and safety of Lyprinol (a patented
extract from Perna Canaliculus), a 5-LOX inhibitor in patients with
osteoarthritis. In this multicenter trial, 60 patients with symptomatic
osteoarthritis of the knee and hip were included to receive Lyprinol at a dose
of 2 capsules twice a day. After a 4- and 8-week treatment period, the following
parameters were analyzed: visual analogue scale; Lequesne functional index;
global assessment by patients; global assessment by physician; and adverse
effects. Lyprinol treatment led to significant improvement of the signs
and symptoms of osteoarthritis as determined by all efficacy measures. After a
4- and 8-week treatment period, 53% and 80% (respectively) of patients
experienced significant pain relief, and improvement of joint function. There
was no reported adverse effect during this clinical trial. Lyprinol
was very effective and is a promising anti-inflammatory product that relieves
the signs and symptoms of osteoarthritis, without adverse effect.
Bierer TL, Bui LM. Improvement of arthritic signs in dogs fed green-lipped
mussel (Perna canaliculus). J Nutr. 2002 Jun;132(6 Suppl 2):1634S-6S.
Couch RA, Ormrod DJ, Miller TE, Watkins WB. Anti-inflammatory activity in
fractionated extracts of the green-lipped mussel. N Z Med J. 1982 Nov
24;95(720):803-6.
Emerlyanov, A. Treatment of asthma with lipid extract of New Zealand green-lipped
mussel: a randomised clinical trial. Eur Respir J. 2002 Sep;20(3):596-600.
Halpern GM. Anti-inflammatory effects of a stabilized lipid extract of Perna
canaliculus (Lyprinol). Allerg Immunol (Paris). 2000 Sep;32(7):272-8.
Home - Tribulus Terrestris Extract
Lyprinol arthritis research studies will be reviewed
periodically and this page will be updated. We hope additional research with Lyprinol mussel
extract perna canaliculus and its role in asthma will provide us with guidance
as to the appropriateness of these pills to be taken for health conditions.