Longevity
supplement
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A new report issued by the National Center for Health Statistics indicates
improved longevity in the US.
American adults are living longer, fewer babies are dying in infancy, and the gap between
white and black life expectancy has narrowed during the past decade. In 2000, average life
expectancy at birth hit record highs, with men at 74.1 years and women at 79.5 years. A
century earlier, life expectancy was 48 years for men and 51 years for women. Those who
reach age 65 now live to an average age of 81 for men and 84 for women. It is
unclear whether this trend in longevity will continue.
2001--For men, life expectancy rose from 74.3 in 2000 to 74.4 years in 2001. Women's life
expectancy rose from 79.7 to 79.8 years. White women have the highest life expectancy,
80.2 years, followed by black women (75.5 years), white men (75 years) and black men (68.6
years).
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Longevity
supplements
The field of longevity and anti-aging is full of promises and
unsubstantiated claims. As of now, there is no definitive research in humans of any
substances or techniques that have been proven to extend longevity. However, there are a
number of steps we can take to potentially live longer. These include:
Longevity enhancers
1. Have a positive attitude and improve your coping skills to daily stresses.
Embrace the philosophy that "It's not what happens to me, it's what I make of
it."
In a sample of people aged 50 and
older who were followed for an average of 23 years, respondents who reported having a
positive attitude toward aging lived an average of more than 7 years longer than those who
had a more dismal view of getting older. Do you want to be happier? Take a look
at my book on Happiness.
2. Keep a healthy weight and reduce the
number of calories consumed. Caloric restriction prolongs life in animals.
Cutting calories may do more than help people shed excess weight, research suggests.
According to a new report, a low-calorie diet may also slow age-related changes in the
heart's genes that can lead to chronic disease. In the study, "middle-aged"
14-month-old mice were fed either a normal diet or one restricted in calories. When the
mice reached 30 months of age, or the equivalent of 90 years of a human life span, the
researchers analyzed their heart tissue. The hearts of mice on the low-calorie diets
showed nearly 20% fewer age-related genetic changes and also appeared to have less DNA
damage than those of mice on regular diets. Restricting calories also inhibited
potentially disease-causing changes in the immune system, and suppressed apoptosis, or
programmed cell death.
A telephone poll conducted
by ABC News found that 73% of respondents would not restrict their caloric intake in order
to live longer.
Mouse
study: eating
less at any age prolongs life.
3. Reduce consumption of foods cooked at high temperature
4. Regular exercise and keep physically active.
Regular stretching or yoga is
helpful in keeping joints and ligaments supple. Older adults who are able to
boost their walking speed over time live longer lives. Testing older patients'
walking speed could be one simple way to predict long-term health and survival.
A study of 439 adults age 65 and older, found that those who improved their
walking speed over one year were less likely to die over the next eight years.
5. Avoid smoking cigarettes.
Smokers die ten years younger on average than non-smokers
As if smokers need another reason to
kick the habit, California scientists have discovered that nornicotine, a byproduct of
nicotine, the substance that makes cigarettes so addictive, causes a type of chemical
reaction in the body similar to that which occurs when sugar is scorched or food goes bad.
This reaction is thought to play a role in diabetes, cancer and other diseases. The
interaction between sugars and proteins can produce substances called advanced glycation
endproducts, or AGEs. The accumulation of AGEs appears to contribute to the aging process
and certain diseases.
6. Have strong connections to others, whether through family and relatives, marriage,
children, pets, or connecting with nature, planet earth, and the universe.
7. Get a deep sleep
8. Keep your mind young and active by learning.
9. Try to surround yourself with nature. Green trees in the neighborhood, sunshine in
home, are linked to longevity.
Unfortunately, one of the most important influences on longevity is genetics, something we
cannot influence with our present scientific knowledge. People who have parents and
grandparents who live long are more likely to also live a long life.
Additional potential longevity enhancers:
Being financially stable
Having a satisfying career
Healing old and new emotional wounds
Having a personal religious or philosophical belief system that gives meaning to this
world.
Driving safely, wearing seat belts, minimizing the use of cell phones while driving.
Supplements for Longevity
There is currently no evidence that taking supplements or hormones (such as growth
hormone) will make us live longer. However, it seems reasonably safe to take small amounts
of certain supplements that have shown preliminary research to be helpful.
Antioxidants
Acetyl-l-carnitine
and Lipoic Acid are interesting nutrients that may be beneficial, more
research is needed before making recommendations.
Carnosine
appears to be able to extend the lifespan of cultured cells, and rejuvenate
senescent cells.
Longevity fact
Japanese girls born in 2007 can expect to live until they are 86 years
old, which would make them the longest survivors in the world. Boys born
in 2007 can expect to live to the age of 79, ranking third after Iceland
and Hong Kong.
Longevity Research Update
Use of carnosine as a natural anti-senescence drug for human beings.
Wang AM, Ma C, Xie ZH, Shen F.Biochemistry (Mosc) 2000 Jul;65(7):869-71.
Department of Biochemistry, Harbin Medical University, Harbin 150086, PR China.
Carnosine is an endogenous free-radical scavenger. The latest research indicates
that apart from the function of protecting cells from oxidation-induced stress damage,
carnosine appears to be able to extend the lifespan of cultured cells, rejuvenate
senescent cells, inhibit the toxic effects of amyloid peptide (A beta), malondialdehyde,
and hypochlorite to cells, inhibit glycosylation of proteins and protein-DNA and
protein-protein cross-linking, and maintain cellular homeostasis. Also, carnosine seems to
delay the impairment of eyesight with aging, effectively preventing and treating senile
cataract and other age-related diseases. Therefore, carnosine may be applied to human
being as a drug against aging.
Foods cooked at high heat
linked to inflammation
People may be able to lower their risk of heart, diabetes, and possibly other
diseases by consuming cool foods, or dishes cooked at relatively low temperatures, such as
salads and tuna fish, preliminary research suggests.
Foods cooked at high temperatures spurred the
production of advanced glycation end products (AGEs), compounds in the blood
that stimulate cells to produce inflammation. While AGEs are normally produced in the body at a
slow rate, they can be toxic and form more quickly when food is heated to high
temperatures. Inflammation is associated with heart disease among all people, but people
with diabetes are thought to be particularly vulnerable. People who consumed foods cooked at lower
temperatures had lower levels of both AGEs and inflammatory proteins than people who
consumed the same foods cooked at higher temperatures. After 6 weeks, levels of tumor
necrosis factor-alpha (TNF-alpha) and concentrations of the inflammatory protein
C-reactive protein (CRP) had also risen among those consuming the diet high in AGEs and
declined among those in the reduced AGE group. TNF-alpha and CRP are both markers showing
increased inflammation.
November 2006 Longevity Report
Americans are living longer, with
life span at a record average of just short of 80 years, according to the annual
report on the nation's health from the Centers for Disease Control and
Prevention. At birth, life expectancy for females is just over 80 years and
nearly 75 for males. The gap in life expectancy between white and black
Americans also has narrowed from seven years in 1990 to five years in 2004. Life
expectancy at birth reached a record 77.9 years in 2004, up from 77.5 in 2003
and from 75.4 in 1990.
2004 - A report issued by the National Center for Health Statistics indicates
improved longevity in the US.
American adults are living longer, fewer babies are dying in infancy, and the gap between
white and black life expectancy has narrowed during the past decade. In 2000, average life
expectancy at birth hit record highs, with men at 74.1 years and women at 79.5 years. A
century earlier, life expectancy was 48 years for men and 51 years for women. Those who
reach age 65 now live to an average age of 81 for men and 84 for women. It is
unclear whether this trend in longevity will continue.
2001--For men, life expectancy rose from 74.3 in 2000 to 74.4 years in 2001. Women's life
expectancy rose from 79.7 to 79.8 years. White women have the highest life expectancy,
80.2 years, followed by black women (75.5 years), white men (75 years) and black men (68.6
years).
The field of longevity and anti-aging is full of promises and unsubstantiated claims. As of now, there is no definitive research in humans of any substances or techniques that have been proven to extend longevity. However, there are a number of steps we can take to potentially live longer. These include:
Additional potential longevity enhancers:
Being financially stable
Having a satisfying career
Healing old and new emotional wounds
Having a personal religious or philosophical belief system that gives meaning to this
world.
Driving safely, wearing seat belts, minimizing the use of cell phones while driving.
Supplements for Longevity
There is currently no evidence that taking supplements or hormones (such as growth
hormone) will make us live longer. However, it seems reasonably safe to take small amounts
of certain supplements that have shown preliminary research to be helpful.
Longevity Gene
A variation in a particular gene involved in regulating cholesterol is known to
be associated with longevity, and now it seems it also confers mental sharpness
in old age. Researchers examined whether a variant of the CETP gene, called the
V type, played a role in preserving cognitive function in 158 Ashkenazi Jews
with exceptional longevity. Their average age was 99.2 years. Overall, 29
percent of the subjects with good cognitive function had the V type CETP gene,
compared to 14 percent with poor cognitive function. Looked at the other way, 61
percent of those with the V type had good cognitive function versus 30 percent
of those with another type. The team then studied 173 subjects from the Einstein
Aging Study to confirm the role of CETP in a younger cohort. The CETP V type was
approximately five times more common in subjects without dementia than in those
with dementia. Neurology, December 2006.
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