L-Carnitine
supplement l carnitine, carnitine side effects, deficiency,
information carnitine
Carnitine, or L-carnitine, is a naturally occurring
substance found in most cells of the body, particularly the brain and neural tissues,
muscles, and heart. Carnitine, whose structure is similar to choline, is widely available
in animal foods (meat, poultry, fish and dairy products), whereas plants have very small amounts. Most
non-vegetarians consume about 100 to 300 mg of carnitine a day, and the body is
able to synthesize this nutrient if dietary intake is inadequate.
L carnitine for cancer
patients who have fatigue
Safety, tolerability and symptom outcomes associated with L-carnitine
supplementation in patients with cancer, fatigue, and carnitine deficiency: a
phase I/II study. J Pain Symptom Manage. 2006 December. Cruciani RA, Dvorkin E, Homel P,
Malamud S, Culliney B, Lapin J, Portenoy RK, Esteban-Cruciani N. Department of
Pain Medicine and Palliative Care, Beth Israel Medical Center, New York 10003,
USA.
L Carnitine deficiency is among the many metabolic disturbances that may
contribute to fatigue in patients with cancer. Administration of exogenous L-carnitine
may hold promise as a treatment for this common symptom. Little is known about
L-carnitine safety, tolerability, and dose-response in patients with cancer. We
conducted a Phase I/II open-label trial to assess the safety and tolerability of
exogenous L-carnitine and clarify the safe dose range associated with symptom
effects for future controlled trials. Adult patients with advanced cancer,
carnitine deficiency, moderate to severe fatigue, and a Karnofsky Performance
Status (KPS) score > or =50 were entered by groups of at least three into a
standard maximum tolerated dose design. Each successive group received a higher
dose of L-carnitine (250, 750, 1250, 1750, 2250, 2750, 3000 mg/day,
respectively), administered in two daily doses for 7 days. These findings
suggest that l-carnitine may be safely administered at doses up to 3000 mg/day
and that positive effects may be more likely at relatively higher doses in this
range. This study provides the basis for the design of future placebo-controlled
studies of l-carnitine supplementation for cancer-related fatigue.
L carnitine for patients
with thalassemia
Effect of L-carnitine on the physical fitness of thalassemic patients. Ann Hematol. 2007 January. El-Beshlawy A, El Accaoui R, Abd El-Sattar
M, Gamal El-Deen MH, Youssry I, Shaheen N, Hamdy M, El-Ghamrawy M, Taher A.
Department of Pediatrics, New Children Hospital, Cairo University, Cairo, Egypt.
Poor physical fitness is a common problem among thalassemic patients. L-Carnitine
plays an essential role in fatty acid beta-oxidation, a process especially
important in the organs that preferentially use fatty acid as a source of energy
such as the myocardium and the skeletal muscles. The main objective of this
study is to assess the effect of the administration of oral L-carnitine on
exercise tolerance and physical fitness in patients with thalassemia major.
Thirty patients followed up at the New Cairo University Children Hospital were
included in this study. Clinical, laboratory, and cardiopulmonary exercise
testing were performed before and after 6 months of oral L-carnitine therapy (50
mg per kg per day). The oxygen consumption, cardiac output, and oxygen pulse at
maximal exercise significantly increased after L-carnitine therapy. However,
there was no significant change in minute ventilation and ventilatory equivalent
of carbon dioxide. There was also significant increase in the blood transfusion
intervals after L-carnitine administration. However, there was no significant
change in hemoglobin concentration. L-Carnitine seems to be a safe and effective
adjunctive therapeutic approach in thalassemic patients. It improves their
cardiac performance and physical fitness. The younger the patients are, the
higher is the degree of improvement in their exercise parameters.
L-Carnitine 250
mg, 250 Capsules Jarrow
L-Carnitine is an amino acid found in high
concentrations in human heart and liver tissue, where it participates in
metabolizing fatty acids into energy by the mitochondria.
L-Carnitine also facilitates the metabolism of carbohydrates and enhances
the rate of oxidative phosphorylation.
L-Carnitine works synergistically with Co-Q10, an antioxidant and energy
co-factor that is found in the inner membrane of the mitochondria.
L-CarniPure L-Carnitine is manufactured by Lonza, the industry leader
offering the finest L-Carnitine in the world.
L-Carnitine 500 mg, 100
Capsules
Jarrow Formulas L-Carnitine is an amino acid found in high
concentrations in human heart and liver tissue, where it participates in
metabolizing fatty acids into energy by the mitochondria. L-Carnitine
also facilitates the metabolism of carbohydrates and enhances the rate of
oxidative phosphorylation.
L-Carnitine works synergistically with Co-Q10, an antioxidant and energy
co-factor that is found in the inner membrane of the mitochondria.
L-CarniPure L-Carnitine is manufactured by Lonza, the industry leader
offering the finest L-Carnitine in the world.L-Carnitine Tartrate is a superior, stable form of L-Carnitine
and is 67% elemental carnitine. 750 mg of L-Carnitine Tartrate yields 500 mg
elemental L-Carnitine.
L Carnitine questions
Q. Could you explain the difference in benefits between Acetyl-L-Carnitine and
L-Carnitine ?
A. Acetyl-L-Carnitine is the acetyl form of L-Carnitine. Acetyl-L-Carnitine
has a quicker effect on mental function than L-Carnitine which is more
useful for overall physical energy.