Icariin
for impotence
icariin research
Icariin, a flavonol glycoside, is an interesting substance found in
certain herbs, particularly horny goat weed.
Icariin is a flavonoid with a rhamnose as
ligand. Horny goat weed is widely used for the treatment of atherosclerosis and
neuropathy in Chinese traditional medicine.
Icariin and Erections
Icariin appears to have some properties similar to Viagra. Icariin is a cGMP-specific PDE5 inhibitor that may
have potential in treating erectile dysfunction.
Epimidium Sagittatum, 400 mg,
medical doctor formulated
Epimedium
sagittatum has an interesting flavonoid
called icariin. In China it is
especially used for supporting healthy sexual activity - thus its name,
Horny Goat Weed.
Epimedium sagittatum 400 mg has epimedium extract (standardized to 10% flavonoids as icariin).
Epimedium sagittatum Supplement
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Additional icariin benefits
In laboratory studies, icariin appears to have anti- cancer abilities. Icariin
also helps protect the liver from toxicity.
Icariin and mood
Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine
levels in stressed Sprague-Dawley rats.
Biol Pharm Bull. 2006 Dec;29(12):2399-403. State Key Laboratory of
Pharmaceutical Biotechnology, Nanjing University, China.
Icariin is one of the major active flavonoids constituents of Epimedium
brevicornum MAXIM (Berberidaceae). Icariin and Epimedium brevicornum have a wide
range of pharmacological activities. Abnormality in the
hypothalamic-pituitary-adrenal (HPA) axis is considered to be a key
neurobilogical factor in major depression, and cytokines have a close
relationship with the activation of the HPA axis. In the present study, the aim
was to determine whether icariin possesses an antidepressant-like activity, and
to explore the effects of icariin on the HPA axis and cytokine levels in chronic
mild stress model of depression in Sprague-Dawley rats. These results suggested that icariin possessed an
antidepressant-like property that was at least in part mediated by
neuroendocrine and immune systems.
Icariin
and erection research
Effects of icariin on intracavernosal pressure and systematic arterial blood
pressure of rat
Department of Urology, People's Hospital affiliated to Wuhan University, Wuhan
430060, China.
Zhonghua Yi Xue Za Zhi. 2004 Jan;84(2):142-5.
To realize the effect of icariin on erectile function of penis.
Icariin of different concentrations
was administrated intracavernosally. Sildenafil and papaveine were used as
controls. Icariin increases
intracavernous pressure.
For more information on erectile
dysfunction herbs.
Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.
Department of Urology, the 1st Hospital, Peking University, 8 Xishiku Street,
Xicheng District, Beijing 100034, China.
Asian J Androl. 2003 Mar;5(1):15-8.
To clarify the mechanism of the therapeutic action of icariin on erectile
dysfunction (ED). PDE5 was isolated from human platelet and PDE4 from the rat
liver tissue. The inhibitory effects of icariin on PDE5 and PDE4
activities were investigated. Papaverine served as the control drug. Icariin
and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4
activities. The potencies of selectivity of icariin and papaverine
on PDE5 (PDE4/PDE5 of IC(50)) were 167 times and 4 times, respectively. Icariin is a cGMP-specific PDE5 inhibitor that may be developed into
an oral effective agent for the treatment of ED.
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