Horse chestnut extract pill
Horse chestnut extract for varicose veins horse chestnut

Most studies show horse chestnut is useful in the therapy of chronic venous insufficiency. Diseases of the venous system are widespread disorders sometimes associated with modern civilization and are among the major concerns of social and occupational medicine. Grape seed extract may also be helpful for venous insufficiency. For more horse chestnut information or to buy Horse-Chestnut extract. Compression stocking therapy and horse chestnut seed extract therapy are alternative medicine therapies for the effective treatment of patients with edema resulting from chronic venous insufficiency.

Substances in horse chestnut seed
 Flavonoids are present in a horse chestnut extract in a relatively high amount, including beta-aescin.

Horse chestnut study
The aim of this study was to compare the efficacy of Venostasin (600 mg of horse chestnut seed extract) and 360 mg of Pycnogenol (French maritime pine bark extract) in the treatment of chronic venous insufficiency (CVI). Pycnogenol was found to be more efficacious than Venostasin for the treatment of CVI. Those taking the pycnogenol had a reduction in leg pain and swelling.

Genetiic cause of vein problems
Simple genetics may explain why some people get varicose veins, the unsightly, painful bulges that appear on the legs when blood pools in the veins. Researchers based in Scotland report that people whose mother, father, brother or sister has varicose veins are more likely than those with no family history to develop the condition. In contrast with previous research, the investigators did not discover any relationship between varicose vein risk and certain lifestyle factors such as diet, smoking and mobility at work. Varicose veins also occurred more commonly among men, a finding that contradicts previous research showing varicose veins appear more commonly in women. Men and women who were relatively tall and women who were obese were also more likely to show signs of varicose veins than others.

Horse chestnut for venous insufficiency
Rational therapy of chronic venous insufficiency -- chances and limits of the therapeutic use of horse-chestnut seeds extract.
Ottillinger B, Greeske K. BMC Cardiovasc Disord. 2001;1(1):5. Epub 2001 Dec 07.
We report two clinical studies, one already published, performed in patients with early and advanced chronic venous insufficiency (CVI). In both, compression therapy and oral therapy with horse-chestnut seeds extracts were compared to placebo. The published study in early CVI (Grade I) showed horse-chestnut and compression to be superior to placebo and to be equivalent to each other in reducing lower leg volume, a measure for oedema.In the study, in advanced CVI (Grade II and IIIa), compression appeared to be superior to placebo, whereas horse-chestnut was not. Horse-chestnut fared better in Grade II than in Grade IIIa patients.These results are discussed in the light of data from an in vitro model, where horse-chestnut has been able to close the intercellular gaps in the venular endothelium. Not fully specified factors lead to an opening of these gaps, resulting in oedema as well as in local coagulation and thrombosis. The subsequent inflammation keeps these gaps open and initiates and maintains a chronic disease process, which may be the starting point of CVI. Due to its ability to close the venular endothelial gaps, horse-chestnut seems to be a suitable and protecting therapy during the early stages of CVI. In later more severe stages compression therapy is indicated. Taking into account the observed negative impact of compression on quality of life, pharmacological CVI therapy should start early to avoid progress and to spare patients compression therapy.

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