Good Night Rx with hops plant extract for deeper sleep
Hops
Supplement Facts:Hops (flower)
Click here to buy Hops flowers supplement, to buy Good Night Rx herbal formula with hops for deeper sleep
Hops
herb research and anxiety, will this
help help you sleep better?
Hops is useful as a sleep inducer, has antioxidant activity, estrogen-like
properties, and potential anti-tumor activity. Furthermore, compounds in hops
reduce insulin resistance. This herb, either as a capsule or in tea form, can
help you sleep
better.
Nature's Way Hops Flowers, 310 mg
Good Night Rx with hops plant extract for deeper sleep
Hops
Supplement Facts:
Hops (flower)
Click here to buy Hops flowers supplement, to buy Good Night Rx herbal formula
with hops for deeper sleep
Hope as
anti-inflammatory
Metagenics, Inc., a developer and manufacturer of medical foods and
nutraceuticals sold through healthcare practitioners, announced the publication
of a scientific paper, “Safety, efficacy and anti-inflammatory activity of rho
iso-alpha-acids from hops,” in the May 2008 issue of Phytochemistry, the
International Journal of Plant Chemistry, Plant Biochemistry and Molecular
Biology.
Previous work by the Metagenics MetaProteomics nutrigenomics research center had
identified a defined mixture of rho iso-alpha-acids (RIAA), a derivative of hops
(Humulus lupulus L.), as a selective COX-2 inhibitor. The Phytochemistry paper
summarizes the results of several new studies conducted by Metagenics evaluating
the efficacy and safety of RIAA. Among the findings:
Clinically, the hops extract rho iso-alpha-acids mixture produced a
reduction in WOMAC Global scores (a standard measurement used to assess the
symptoms of pain, stiffness and physical function), in patients exhibiting knee
osteoarthritis.
Rho iso-alpha-acids was shown to selectively inhibit the inducible
(inflammatory) activity of COX-2 without affecting constitutive (housekeeping)
COX-2 activity.
According to Jeffrey S. Bland, PhD, Metagenics Chief Science
Officer and President of MetaProteomics, “Based on our cumulative research, RIAA
appears to have the potential to serve as a safe and efficacious option in some
areas where specific COX-2 inhibitors have been traditionally used. We’re
excited about the possibilities in helping millions of people who are looking
for safer approaches for pain relief.”
Hops and Cancer
Extracts of several estrogenic herbs, including hops, black cohosh and vitex,
inhibited growth of breast cancer cells. These in vitro results suggest that certain herbs
and phytoestrogens may have potential in the prevention of breast cancer.
Six flavonoids from hops (Humulus lupulus) were tested for their antiproliferative
activity in human breast cancer (MCF-7), colon cancer (HT-29) and ovarian cancer. All the
hop flavonoids were cytotoxic in the three cell lines. As antiproliferative agents,
chalcone and its (flavanone isomer may have potential chemopreventive activity against
breast and ovarian cancer in humans.
A potent phytoestrogen in hops, 8-prenylnaringenin, has an activity greater than other
established plant estrogens. The estrogenic activity of this compound was reflected in its
relative binding affinity to estrogen receptors from rat uteri. The presence of
8-prenylnaringenin in hops may provide an explanation for the accounts of menstrual
disturbances in female hop workers. This phytoestrogen can also be detected in beer, but
the levels are low and should not pose any cause for concern.
Hops phytoestrogen
A potent phytoestrogen in hops, 8-prenylnaringenin, has an activity greater than other
established plant estrogens. The estrogenic activity of this compound was reflected in its
relative binding affinity to estrogen receptors from rat uteri. The presence of
8-prenylnaringenin in hops may provide an explanation for the accounts of menstrual
disturbances in female hop workers. This phytoestrogen can also be detected in beer, but
the levels are low and should not pose any cause for concern.
Sleep
Valerian
and hops are traditionally used as sleep-inducing herbs. When the
chemical adenosine is released in the frontal basal cortex, sleep is induced.
Valerian has an adenosine like action and supports the readiness to fall asleep.
The control of the sleep-wake rhythm induces sleep when the time-related
interaction is operating properly. The control is closely related to melatonin
secretion. Hops act in a similar way to melatonin. Therefore there is benefit of
a valerian and hops combination in inducing sleep.
Melatonin pill is often used for better sleep and can be combined with
herbal insomnia remedies.
Comparative study for assessing quality of life of
patients with exogenous sleep disorders (temporary sleep onset and sleep
interruption disorders) treated with a hops-valarian preparation and a
benzodiazepine drug]
Schmitz M, Jackel M. Institut fur
Psychosomatik, Wien.
Wien Med Wochenschr. 1998;148(13):291-8.
This randomized, double-blind, controlled clinical trial in parallel group
design demonstrated equivalent efficacy and tolerability of a hop-valerian
preparation compared with a benzodiazepine preparation in patients suffering
from sleep disorders according to DSM-IV criteria. Sleep quality, fitness and
quality of life were determined by psychometric tests, psychopathologic scales
and sleep-questionnaires at the beginning of the therapy, end of therapy
(duration 2 weeks) and then 1 week after cessation of therapy. The equivalence of both therapies according to sleep
quality, fitness and quality of life was proven. The patients'
state of health improved during therapy while showing a deterioration after
cessation with both preparations. Withdrawal symptoms, however, were documented
with benzodiazepine. Only one adverse drug reaction was reported during this
study, namely stomach complaints from both the test and reference medication.
This study shows that the investigated hop-valerian preparation in the
appropriate dose is a sensible alternative to benzodiazepine for the treatment
of nonchronic and non-psychiatric sleep disorders.
Hops Flowers
Nature's Way
Hops
(Humulus lupulus) is a perennial native British plant with a stout root. It has
heart-shaped leaves and cone-like flowers. Romans ate the young shoots in the
spring in the same way we do asparagus. Hops was first used by breweries in the
Netherlands in the early fourteenth century. Hops has been used traditionally
for nervous disorders.
Hops study Update
Isohumulones, bitter acids derived from hops, activate both peroxisome
proliferator-activated receptor (PPAR) alpha and gamma and reduce insulin
resistance.
Yajima H,. Kirin Brewery Co., Ltd, Yokohama, Yokohama
236-0004.
J Biol Chem. 2004 Jun 3
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid
sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic
effects of fibrate drugs and the therapeutic benefits of the thiazolidinedione
drugs are due to their activation of PPARs alpha and gamma, respectively. In
this study, isohumulones, the bitter compounds derived from hops that are
present in beer, were found to activate PPARs alpha and gamma in transient co-transfection
studies. Among the three major isohumulone homologs, isohumulone and
isocohumulone were found to activate PPARs alpha and gamma. Diabetic KK-A(y)
mice that were treated with isohumulones (isohumulone and isocohumulone) showed
reduced plasma glucose, triglyceride, and free fatty acid levels (65.3, 62.6,
and 73.1%, respectively for isohumulone); similar reductions were found
following treatment with the thiazolidinedione drug, pioglitazone. Isohumulone
treatment did not result in significant body weight gain, though pioglitazone
treatment did increase body weight. C57BL/6N
mice fed a high fat diet that were treated with isohumulones showed improved
glucose tolerance and reduced insulin resistance. Furthermore, these animals
showed increased liver fatty acid oxidation and a decrease in size, and increase
in apoptosis, of their hypertrophic adipocytes. A double-blind,
placebo-controlled pilot study for studying the effect of isohumulones on
diabetes suggested that isohumulones significantly decreased blood glucose and
hemoglobin A1c levels after eight weeks (by 10.1% and 6.4%, respectively, vs.
week zero). These results suggest that isohumulones can improve insulin
sensitivity in high fat diet-fed mice with insulin resistance and in patients
with type 2 diabetes.