Nature's
Way
Guggul (6% Guggulsterones E &Z), 60 Vcaps
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Nature's
Way
Guggul Extract ( Commiphora mukul) is
standardized to 6% guggulsterones E & Z. Guggul has been clinically
shown to promote cardiovascular health.
Guggul extract Supplement Facts:
Guggul extract - 425 mg
(gum resin), 6% guggulsterones E & Z
* Guggul Daily Value not established
Guggul and inflammation
Guggul also has anti-inflammatory activity.
One study reports that it may be beneficial in
osteoarthritis.
Myrrhanol A, a new triterpene isolated from guggul (Balsamodendron or
Commiphora mukul Hook.)-gum resin, displays a potent anti-inflammatory effect.
Guggul dosage
The dosage of guggulsterones is 25 mg two or three times daily. Most extracts contain
2.5–5% guggulsterones and can be taken daily for 3 to six months.
Guggul and memory
Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties,
has protective effects against streptozotocin-induced memory deficits in mice.
Pharmacol Biochem Behav. 2007 April. Division of Pharmacology, Central
Drug Research Institute, Lucknow 226001, India.
Gugulipid, an ethyl acetate extract of the resin of plant guggul is an
established hypolipidemic agent in clinical practice. The major constituent of
gugulipid is guggulsterone [4, 17 (20)-pregnadiene-3, 16-dione]. The present
study was planned to explore the potential of gugulipid as cognitive enhancer.
Gugulipid (12.5, 25 and 50 mg/kg, p.o.) showed dose dependent improvement in
scopolamine-induced deficits in passive avoidance test. Our observations suggest
gugul as a potential anti-dementia drug.
Guggul summary
Guggul appears to be beneficial in those who have metabolic syndrome which
includes high blood lipids, high blood sugar, obesity, and an overall
inflammatory pattern.
Nature's
Way
Guggul (Standardized 6%
Guggulsterones E &Z)
Guggul Extract ( Commiphora mukul) is
standardized to 6% guggulsterones E & Z. Guggul has been clinically
shown to promote cardiovascular health.
Guggul, dried extract (gum resin), 6% guggulsterones E & Z
Guggul
study
Guggulipid for the treatment of hypercholesterolemia: a
randomized controlled trial.
Szapary PO. niversity of Pennsylvania School of Medicine,
Philadelphia 19104-6021, USA.
JAMA. 2003 Aug 13;290(6):765-72.
Recently, guggulsterones, the purported bioactive compounds of
guggul, have been shown to be potent antagonists of 2 nuclear hormone receptors
involved in cholesterol metabolism, establishing a plausible mechanism of action
for the hypolipidemic effects of these extracts. However, there are currently no
published safety or efficacy data on the use of guggul extracts in Western
populations. To study the short-term safety and efficacy of 2 doses
of a standardized guggul extract (guggulipid, containing 2.5% guggulsterones) in
healthy adults with hyperlipidemia eating a typical Western diet. Oral, 3 times daily doses of
standard-dose guggul (1000 mg), high-dose guggul (2000 mg), or matching
placebo. MAIN Percentage change in levels of directly measured
low-density lipoprotein cholesterol (LDL-C) after 8 weeks of therapy. Secondary
outcome measures included levels of total cholesterol, high-density lipoprotein
cholesterol (HDL-C), triglycerides, and directly measured very low-density
lipoprotein cholesterol (VLDL-C), as well as adverse events reports and
laboratory safety measures including electrolyte levels and hepatic and renal
function. Compared with participants randomized to placebo, in
whom levels of LDL-C decreased by 5%, both standard-dose guggul and
high-dose guggul raised levels of LDL-C by 4% and 5%, respectively, at 8 weeks, for a net positive change
of 9% to 10%. There were no significant changes in levels of total cholesterol, HDL-C, triglycerides, or VLDL-C in response to treatment with guggul in the
intention-to-treat analysis. While guggul was generally well tolerated, 6
participants treated with guggul developed a hypersensitivity rash compared
with none in the placebo group. Despite plausible mechanisms of
action, guggul did not appear to improve levels of serum cholesterol over
the short term in this population of adults with hypercholesterolemia, and might
in fact raise levels of LDL-C. Guggulipid also appeared to cause a dermatologic
hypersensitivity reaction in some patients.
The effectiveness of Commiphora mukul (guggul) for osteoarthritis of
the knee: an outcomes study.
Singh BB,.
Southern California University of Health Sciences, USA.
Altern Ther Health Med. 2003 May-Jun;9(3):74-9.
Ayurveda, the traditional system of healthcare in India, has many
remedies for Osteoarthritis (OA). One of the ingredients most commonly found in
Ayurvedic arthritis formulas is guggul, an oleoresin of the herb Commiphora
mukul. The authors have conducted both preclinical and clinical
investigations of guggul for reduction of pain, stiffness, and improved
function, and to determine tolerability in older patients with a diagnosis of OA
of the knee. The study was conducted using an outcome,
quasi-experimental, model. Thirty male and female participants meeting the
inclusion/exclusion criteria, with a score of 2 or more on the Kellegran-Lawrence
scale for at least 1 knee, were admitted in the study. Guggul was administered in
capsule form (500 mg concentrated exact delivered TID) along with food. The
WOMAC Total Score was used as a primary outcome measure. VAS scales, 6-minute
walk-test, and WOMAC subscales were used as outcome measures. At the
end of treatment, there was a significant difference in the scores of the
primary and secondary outcome measures. On the primary measure, WOMAC total
score, participants were significantly improved after taking the
supplement for 1 month and continued to improve at the 2-month marker and
follow-up. Secondary measures of pain in the VAS format demonstrated participant
improvement; however, mood state, and current pain were not significantly
different (P < 0.05) than baseline until the 2 month assessment. Overall data indicate significant improvement for participants
during the trial in both scales and objective measures used for assessment
purposes. There were no side effects reported during the trial. Guggul appears to be
a relatively safe and effective supplement to reduce symptoms of OA.
Guggul suppliers
I manage BacfoUSA, a division of Bacfo Pharmaceuticals - one of the
worlds largest manufacturer of ayurvedic herbs.
Our manufacturing facility is ranked top 2% in Asia with ISO 9001:2000, HACCP-IS:
15000, cGMP and GMP manufacturing. Below is a pricelist of a few. For a detailed
list of all our products: www.bacfousa.com or www.bacfo.com
The FOB Delhi price list for Gugguls in Bulk (25kg drums) is:
Kaishore Guggul Powder - $20.50 per kg
Gokshuradi Guggul Powder - $20.50 per kg
Triphala Guggul Powder - $20.50 per kg
Yograj Guggul Powder - $19.50 per kg
Punarnawadi Guggul Powder - $$21.50 per kg
Singhnad Guggul Powder - $20.50 per kg
Kanchanar Guggul Powder - $20.50 per kg
Guggul Powder - $27.50 per kg
Amit Gadhia International Division - USA
901 Bosworth St. Suite C San Francisco, CA 94131
Guggul Emails
Q. Is Guggul only to
be used for three to six months? My cholesterol problem is not dietary, and therefore
would require a product that can be taken indefinitely. Can guggul be used for life?
A. A review of medical studies published in the Western scientific literature does not
show any long term studies with guggul done in humans. Therefore, it is difficult to say whether guggul can be used for life.
Q. My doctor
put me on Lipitor which is a cholesterol reducing statin drug. I have a friend
who studies Ayurvedic medicine and she told me about guggul. Can you tell me
more about this herb, can it be combined with statin drugs?
Guggul (Commiphora mukul) a resin from the guggul tree, has been used for
more than 2,000 years in India to treat a range of disorders. In the 1980s, an
extract of the resin--dubbed guggulipid--began to be marketed as a
cholesterol-lowering agent. The plant compound's mode of action is quite
different from that of cholesterol-lowering statin drugs. This means that it or
other compounds that work similarly could potentially be used in combination
with statins, however no scientific studies have been done combining the two.
Some of guggul's active components, guggulsterones, work by blocking a substance
that stops the body from getting rid of cholesterol. Statins, on the other hand,
block the body from making more cholesterol.
A. In addition to lowering cholesterol, guggul has anti-inflammatory activity. There hasn’t been enough research with
the extracts to determine the side effect profile. The dosage of guggul is about
500 mg twice daily. Most extracts contain 2.5–5% guggulsterones.
Guggul pill questions
Q. Can a guggul pill be taken together with
Elderberry supplement?
A. We have not seen studies with this combination but for short
term use we don't see any major side effects that would occur.
Q. I am taking Abilify and Effexor. Is there any
information regarding guggul supplement with such medications?
A. We have not seen any studies regarding the interactions of
guggul supplement with SSRI drugs or
Abilify, a medication for the treatment of schizophrenia and manic episodes
associated with bipolar disorder.
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