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Erectile dysfunction treatment, medication, drug, herb

Erectile dysfunction can be classified simply under two headings. Psychogenic erectile dysfunction: that is, mental; or Organic erectile dysfunction: that is, due to some form of physical problem. Organic erectile dysfunction becomes more common as men get older.

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Psychological-Mental causes of Erectile Dysfunction
The causes of psychological erectile dysfunction are numerous, and it is difficult to list them all, but most often erectile dysfunction is related to depression, performance anxiety, marital stress or relationship problems, life crisis, financial difficulties, religious repression, or some type of mental illness. For more up to date
erectile dysfunction info.

Organic Erectile Dysfunction usually has 4 major causes

1. Vascular causes of Erectile Dysfunction
Alterations in the flow of blood to and from the penis are thought to be a common cause of male erectile dysfunction. For instance, medical conditions such as atherosclerosis (hardening of the arteries), high cholesterol, high bloos pressure or hypertension, or high blood sugar or diabetes reduce blood flow to the penis and genital organs thus leading to difficulty with erection or genital swelling.  Erectile dysfunction could be an early indication of oxidative stress and vascular dysfunction. A vascular problem in the penis may precede a wider, systemic problem in other blood vessels in the body.
Patients with cardiovascular disease and patients with diabetes represent the largest group of patients with erectile dysfunction. Lowering cholesterol through diet, supplements, or medicines improves erectile dysfunction.
   Additional factors that can impede blood flow include penile injury and surgery in the pelvic and abdominal area. Smoking can reduce genital blood flow.

2. Neural causes of Erectile Dysfunction
Nerve damage from disorders such as multiple sclerosis, Parkinson’s disease, diabetes, and stroke affect the brain’s ability to respond to sexual stimulation and cause erectile dysfunction. In women, abdominal or pelvic operations can occasionally lead to nerve damage. Erectile dysfunction is common in men undergoing surgical treatment for prostate enlargement or cancer.

3. Hormonal causes of Erectile Dysfunction
Low levels of androgens, such as testosterone, are a major component of erectile dysfunction. Testosterone levels decline about 1 percent each year in men, which may contribute to erectile dysfunction with aging. Testosterone also declines with age in women leading to a decrease in female libido. Women who have had surgical removal of the ovaries notice a drop in sexual interest. Replacement of androgens can be helpful in those with age related erectile dysfunction. Testosterone is available by prescription only. An over the counter hormones, such as DHEA, converts into testosterone and thus has a positive influence on erectile dysfunction. Pregnenolone is another over the counter hormone that may increase testosterone levels and thus improve erectile dysfunction. Many herbal aphrodisiacs also have a positive influence on erectile dysfunction.

4. Drug induced
Erectile Dysfunction
Drugs that interfere with erectile function include some anti-hypertensives, SSRIs (like Prozac), sedatives, and beta-blockers. SSRIs cause erectile dysfunction mostly due to their effect on serotonin metabolism. Serotonin has an inhibitory effect on erectile function and sexuality.
  
Some chemicals involved in the human sexual response include dopamine, the neurotransmitter acetylcholine, and nitric oxide. All these three natural chemicals and others can be manipulated n the treatment of erectile dysfunction. Alcohol's negative affect on sex drive increases with age.

Erectile Dysfunction and Medical conditions
Certain medical conditions cause erectile dysfunction or reduce libido, performance, or enjoyment. These include hypertension, diabetes, high cholesterol, cardiovascular disease, obesity, peripheral vascular disease, neurologic disorders, and insomnia.
   Sitting on a bicycle too long. Men who log several thousand miles a year on their mountain bikes suffer scrotal damage that could reduce their fertility or cause erectile dysfunction.

Erectile Dysfunction and Cardiac Patients
Erectile dysfunction is common in cardiac patients and shares the same risk factors - smoking, hypertension, hyperlipidemia and diabetes mellitus. Sexual activity is not unduly stressful to the heart and, providing patients are properly assessed using established guidelines, sexual intercourse can be enjoyed without increased risk. Erectile dysfunction in asymptomatic patients may be a marker of silent vascular disease or increased vascular risk factors and should alert the physician to the need for cardiac risk screening.
   Physical fitness positively influences sexual desire and performance.

A note about Viagra and erectile dysfunction
Viagra (sildenafil), approved by the FDA in 1998, has been the most popular medicine for the treatment of erectile dysfunction. Viagra works very well in dilating blood vessels in the genital region leading to an erection or increased blood flow to the vaginal tissues, however it does little to directly increase libido or sexual arousal. The effect of Viagra is often noticed within an hour after taking a pill of 50 or 100 mg, and ease of erection may last up to 12 hours. Side effects of Viagra include headache, flushes, nasal congestion or runny nose, malaise, nausea, changes in blood pressure, irregular heart beats, visual disturbances including rare cases of blindness, and chest pain. Viagra may cause stickiness of blood platelets.
    We find natural sex boosters quite effective and preferable to pharmaceutical drugs.


Erectile dysfunction in older men
About one third of older men with erectile dysfunction will experience natural remission, with symptoms becoming less severe but not necessarily going away completely. However, another third will experience a worsening this condition over time. erectile dysfunction, which affects more than 150 million men, has received increased attention in recent years due to its high prevalence and the development of drug treatments, such as Viagra. However, little is known about the natural course of erectile dysfunction after onset. Researchers analyzed data for 401 men between 40 and 70 years old with varying degrees of erectile dysfunction who were followed for about 9 years as part of the longitudinal Massachusetts Male Aging Study. The chance of remission declines with age and is lower among heavier subjects...Smoking and poor general health are associated with worsening of erectile dysfunction symptoms. The Journal of Urology, January 2007.

Erectile Dysfunction study For more up to date erection enhancer info.
The etiology of erectile dysfunction and contributing factors in different age groups in Turkey.
Caskurlu T.Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
Int J Urol. 2004 Jul;11(7):525-529.
Abstract Background: The aim of the present study was to determine the pathophysiological factors which cause erectile dysfunction, as well as the risk factors in different age groups in Turkey. Methods: A total of 948 patients with erectile dysfunction who were admitted to three andrology clinics were evaluated in terms of etiological factors. They underwent a multidisciplinary diagnostic evaluation. Erectile dysfunction was classified as primarily organic, primarily psychogenic, mixed or unknown in etiology. Results: Psychogenic erectile dysfunction was diagnosed in 65.4% of the patients and organic erectile dysfunction was diagnosed in 34.6% of patients overall. In patients under 40 years, the rate of psychogenic erectile dysfunction was 83% and the rate of organic erectile dysfunction was 17%, but in the patients over 40 years, the rate of psychogenic erectile dysfunction was 40.7% and the rate of organic erectile dysfunction was 59.3%. The causes of organic erectile dysfunction were identified as arteriogenic erectile dysfunction, 40.5%; cavernosal factor (venogenic) erectile dysfunction, 10%; neurogenic erectile dysfunction, 12.5%; endocrinologic erectile dysfunction, 1.8%; mixed type erectile dysfunction, 11.8%; and drug induced erectile dysfunction, 4.5%. Conclusion: Our data represent a higher ratio of erectile dysfunction in patients under 40, which are mostly psychogenic, This finding potentially results from local social and cultural differences.

Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: a clinical observation.
Saltzman EA. Lahey Clinic Northshore, Peabody, Massachusetts 01960, USA.
J Urol. 2004 Jul;172(1):255-8.
We determined that use of a statin drug to lower cholesterol would improve erectile function in men who have hypercholesterolemia as the only risk factor for erectile dysfunction. A total of 18 men were determined to have increased cholesterol as the only risk factor for erectile dysfunction by history, system review, physical examination and laboratory analysis. Nine of these men agreed to participate in the study. Organic erectile dysfunction was verified by abnormal nocturnal penile tumescence and rigidity testing. Subjects were given atorvastatin with a goal decrease of total cholesterol to less than 200 mg/dl and low-density lipoprotein cholesterol to less than 120 mg/dl. RigiScan measurements were compared before and after treatment with atrovastatin. RESULTS: Mean age +/- SD was 49.7 +/- 7.4 years. Mean length of treatment with atrorvastatin was 3.7 +/- 2.1 months. Clinically 8 of the 9 men had improved erection adequate for penetration during sexual intercourse. Mean questionnaire scores improved from 14.2 to 20.7 (p <0.001). Mean total and low-density lipoprotein cholesterol decreased significantly after treatment (p <0.001). RigiScan measurements showed an increased average penile rigidity at the base (p <0.001) and tip (p <0.005) after treatment with atorvastatin. Erectile dysfunction improves in men with hypercholesterolemia as the only risk factor for erectile dysfunction when treated with atorvastatin. Treating hypercholesterolemia may improve erectile dysfunction, while promoting primary cardiac prevention.

Exercise and weight loss may improve sexual function in obese men, researchers in Italy report. In a new study of more than 100 obese men with erectile dysfunction, nearly a third regained normal sexual function after participating in an intensive weight loss program.

If a man with type 2 diabetes also suffers from erectile dysfunction, it strongly suggests that he could well have coronary artery disease that's not causing any symptoms, researchers report.

U.S. health regulators have accused Vivus Inc. of misleading consumers by downplaying risks associated with its little-used erectile dysfunction treatment called Muse. Vivus failed to include risk information and made false claims about the drug's effectiveness both on its Web site and in television advertisements that ran in 2003.

Prostate cancer patients underwent an operation called a bilateral nerve-sparing retropubic radical prostatectomy. More than 90 percent of these men who had the operation suffered from erectile dysfunction afterwards.

A third of older men have erectile dysfunction and the problem only gets more common with age. The good news is that there are many things men can do to reduce their risk of erectile dysfunction. The figures come from a survey of nearly 32,000 men, 53 to 90 years of age, who participated in the Health Professionals Follow-up Study. The results are reported in the Annals of Internal Medicine. Dr. Constance G. Bacon, from Harvard School of Public Health, and associates found that 33 percent of the men reported erection problems in the previous 3 months. Moreover, for each decade beyond 50 years of age, overall sexual function, desire, and orgasm frequency decreased sharply. Physical inactivity and obesity had a lot to do with erectile dysfunction. Men who ran for at least 3 hours per week or engaged in a similar amount of exercise were 30 percent less likely to have erectile dysfunction than men who barely exercised at all. Similarly, non-obese men were 30 percent less likely to develop these problems than obese men, the researchers note. Other "risk factors" for erectile dysfunction included smoking, drinking alcohol, and watching television. SOURCE: Annals of Internal Medicine August 5, 2003.
Dr. Sahelian adds: Diet also plays an important role in reducing the risk of erectile dysfunction. I recommend eating lots of healthy, organic vegetables and adding fish to the diet.

Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.

Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J.
Department of Urology, the 1st Hospital, Peking University, 8 Xishiku Street, Xicheng District, Beijing 100034, China.
AIM: To clarify the mechanism of the therapeutic action of icariin on erectile dysfunction. METHODS: PDE5 was isolated from the human platelet and PDE4 from the rat liver tissue using the FPLC system (Pharmacia, Milton Keynes, UK) and the Mono Q column. The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [(3)H]-cGMP/[(3)H]-cAMP. Papaverine served as the control drug. RESULTS: Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities. The IC(50) of Icariin and papaverine on PDE5 were 0.432 micromol/L and 0.680 micromol/L, respectively and those on PDE4, 73.50 micromol/L and 3.07 micromol/L, respectively. The potencies of selectivity of icariin and papaverine on PDE5 (PDE4/PDE5 of IC(50)) were 167.67 times and 4.54 times, respectively. Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of erectile dysfunction.

The symptoms of erectile dysfunction and hypogonadism may be early warning markers of important men's health issues, such as cardiovascular disease, diabetes, metabolic syndrome, depression and benign prostatic hyperplasia.
This means that early detection of erectile dysfunction may be a key factor in early diagnosis and treatment of these serious disorders. Men have always put their health at risk by a macho avoidance of the doctor. Often, by the time a man decides to consult his GP, his condition is already too advanced for successful treatment. Since the arrival of Viagra, Cialis and Levitra, this has changed to a degree in that it has now become slightly more acceptable for men to discuss the problem of ED and perhaps also to talk to a doctor about it. It has now been established that the probability of men suffering from erectile dysfunction increases rapidly with age. Low testosterone levels, or inability to make use effectively of higher levels, results in changes in the penile tissues causing erectile dysfunction. Moderate to long term hormone replacement can reverse these changes and may avert the need for use of more expensive drugs. However, hormone treatment for erectile dysfunction carries risks.

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