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Psychological-Mental causes of Erectile
Dysfunction
The causes
of psychological erectile dysfunction are numerous, and it is difficult to list them all,
but most often erectile dysfunction is related to
depression, performance
anxiety, marital stress
or relationship problems, life crisis, financial difficulties, religious repression, or
some type of mental illness. For more up to date
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dysfunction
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Organic Erectile Dysfunction usually has 4 major causes
1. Vascular causes of Erectile Dysfunction
Alterations in the flow of blood to and from the penis
are thought to be a common cause of male erectile dysfunction. For instance, medical
conditions such as atherosclerosis (hardening of the arteries), high
cholesterol,
high bloos pressure or
hypertension, or
high blood sugar or
diabetes reduce blood flow to the penis and genital organs thus leading
to difficulty with erection or genital swelling. Erectile dysfunction
could be an early indication of oxidative stress and vascular dysfunction. A
vascular problem in the penis may precede a wider, systemic problem in other
blood vessels in the body.
Patients with cardiovascular disease and patients with
diabetes represent the largest group of patients with
erectile dysfunction. Lowering cholesterol through
diet,
supplements, or medicines improves erectile dysfunction.
Additional factors that can impede
blood flow include penile injury and surgery in the pelvic and abdominal area. Smoking can reduce genital
blood flow.
2. Neural causes of Erectile Dysfunction
Nerve damage from disorders such as
multiple
sclerosis, Parkinsons disease, diabetes, and
stroke affect the brains ability to respond
to sexual stimulation and cause erectile dysfunction. In women, abdominal or pelvic operations can occasionally lead to
nerve damage. Erectile dysfunction is common in men undergoing surgical treatment for
prostate enlargement or
cancer.
3. Hormonal causes of Erectile Dysfunction
Low levels of androgens, such as
testosterone, are a major component of erectile dysfunction. Testosterone levels decline about 1 percent each year in men, which may
contribute to erectile dysfunction with aging. Testosterone also declines with age in women
leading to a decrease in
female libido.
Women who have had surgical removal of the ovaries notice a drop in sexual interest.
Replacement of androgens can be helpful in those with age related
erectile dysfunction.
Testosterone is available by prescription only. An over the counter hormones, such as
DHEA, converts into testosterone and thus
has a positive influence on erectile dysfunction.
Pregnenolone is another over the counter hormone that may increase testosterone
levels and thus improve erectile dysfunction. Many herbal
aphrodisiacs also have a positive influence on erectile dysfunction.
4. Drug induced Erectile Dysfunction
Drugs that interfere with erectile function
include some anti-hypertensives, SSRIs (like Prozac), sedatives, and beta-blockers.
SSRIs cause erectile dysfunction mostly due to their effect on
serotonin
metabolism. Serotonin has an inhibitory effect on erectile function and
sexuality.
Some
chemicals involved in the human sexual response include
dopamine,
the neurotransmitter
acetylcholine,
and nitric oxide. All these three natural chemicals and others can be
manipulated n
the treatment of
erectile dysfunction.
Alcohol's negative
affect on sex drive increases with age.
Erectile Dysfunction and Medical conditions
Certain medical conditions cause erectile dysfunction or reduce
libido,
performance, or enjoyment. These include hypertension, diabetes, high
cholesterol, cardiovascular disease, obesity, peripheral vascular disease, neurologic disorders, and
insomnia.
Sitting on a bicycle too long. Men
who log several thousand miles a year on their mountain bikes suffer scrotal
damage that could reduce their fertility or cause erectile dysfunction.
Erectile Dysfunction and Cardiac Patients
Erectile dysfunction is common in
cardiac patients and shares the same risk factors - smoking, hypertension,
hyperlipidemia and diabetes mellitus. Sexual activity is not unduly stressful to
the heart and, providing patients are properly assessed using established
guidelines, sexual intercourse can be enjoyed without increased risk. Erectile
dysfunction in asymptomatic patients may be a marker of silent vascular disease
or increased vascular risk factors and should alert the physician to the need
for cardiac risk screening.
Physical
fitness positively influences sexual desire and performance.
A note about Viagra and erectile dysfunction
Viagra (sildenafil), approved by the FDA in 1998, has been the most popular
medicine for the treatment of erectile dysfunction. Viagra works very well in dilating
blood vessels in the genital region leading to an erection or increased blood flow to the
vaginal tissues, however it does little to directly increase libido or sexual arousal. The
effect of Viagra is often noticed within an hour after taking a pill of 50 or 100 mg, and
ease of erection may last up to 12 hours. Side effects of Viagra include
headache,
flushes, nasal congestion or runny nose, malaise, nausea, changes in blood pressure,
irregular heart beats, visual disturbances including rare cases of blindness, and chest
pain. Viagra may cause stickiness of blood platelets.
We find natural sex boosters quite effective and preferable
to pharmaceutical drugs.
Erectile dysfunction in older men
About one third of older men with
erectile
dysfunction will experience natural remission, with symptoms becoming less
severe but not necessarily going away completely. However, another third will
experience a worsening this condition over time. erectile dysfunction, which
affects more than 150 million men, has received increased attention in recent
years due to its high prevalence and the development of drug treatments, such as
Viagra. However, little is known about the natural course of erectile
dysfunction after onset. Researchers analyzed data for 401 men between 40 and 70
years old with varying degrees of erectile dysfunction who were followed for
about 9 years as part of the longitudinal Massachusetts Male Aging Study. The
chance of remission declines with age and is lower among heavier
subjects...Smoking and poor general health are associated with worsening of
erectile dysfunction symptoms. The Journal of Urology, January 2007.
Erectile Dysfunction study
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The etiology of erectile dysfunction and contributing
factors in different age groups in Turkey.
Caskurlu T.Sisli Etfal Training and Research Hospital, Istanbul,
Turkey.
Int J Urol. 2004 Jul;11(7):525-529.
Abstract Background: The aim of the present study was to determine the
pathophysiological factors which cause erectile dysfunction, as well as the risk
factors in different age groups in Turkey. Methods: A total of 948 patients with
erectile dysfunction who were admitted to three andrology clinics were evaluated
in terms of etiological factors. They underwent a multidisciplinary diagnostic
evaluation. Erectile dysfunction was classified as primarily organic, primarily
psychogenic, mixed or unknown in etiology. Results: Psychogenic erectile
dysfunction was diagnosed in 65.4% of the patients and organic erectile
dysfunction was diagnosed in 34.6% of patients overall. In patients under 40
years, the rate of psychogenic erectile dysfunction was 83% and the rate of
organic erectile dysfunction was 17%, but in the patients over 40 years, the
rate of psychogenic erectile dysfunction was 40.7% and the rate of organic
erectile dysfunction was 59.3%. The causes of organic erectile dysfunction were
identified as arteriogenic erectile dysfunction, 40.5%; cavernosal factor (venogenic)
erectile dysfunction, 10%; neurogenic erectile dysfunction, 12.5%;
endocrinologic erectile dysfunction, 1.8%; mixed type erectile dysfunction,
11.8%; and drug induced erectile dysfunction, 4.5%. Conclusion: Our data
represent a higher ratio of erectile dysfunction in patients under 40, which are
mostly psychogenic, This finding potentially results from local social and
cultural differences.
Improvement in erectile function in men
with organic erectile dysfunction by correction of elevated cholesterol levels:
a clinical observation.
Saltzman EA. Lahey Clinic Northshore, Peabody, Massachusetts 01960, USA.
J Urol. 2004 Jul;172(1):255-8.
We determined that use of a statin drug to
lower cholesterol would improve erectile function in men who have
hypercholesterolemia as the only risk factor for erectile dysfunction. A total of 18 men were determined to have increased cholesterol as
the only risk factor for erectile dysfunction by history, system review,
physical examination and laboratory analysis. Nine of these men agreed to
participate in the study. Organic erectile dysfunction was verified by abnormal
nocturnal penile tumescence and rigidity testing. Subjects were given atorvastatin with a goal decrease of total cholesterol to less than 200 mg/dl
and low-density lipoprotein cholesterol to less than 120 mg/dl. RigiScan
measurements were compared before and after treatment with atrovastatin.
RESULTS: Mean age +/- SD was 49.7 +/- 7.4 years. Mean length of treatment with
atrorvastatin was 3.7 +/- 2.1 months. Clinically 8 of the 9 men had improved
erection adequate for penetration during sexual intercourse. Mean questionnaire
scores improved from 14.2 to 20.7 (p <0.001). Mean total and low-density
lipoprotein cholesterol decreased significantly after treatment (p <0.001).
RigiScan measurements showed an increased average penile rigidity at the base (p
<0.001) and tip (p <0.005) after treatment with atorvastatin.
Erectile dysfunction improves in men with hypercholesterolemia as the only risk
factor for erectile dysfunction when treated with atorvastatin. Treating
hypercholesterolemia may improve erectile dysfunction, while promoting primary
cardiac prevention.
Exercise and weight loss may improve sexual function in obese men, researchers in Italy report. In a new study of more than 100 obese men with erectile dysfunction, nearly a third regained normal sexual function after participating in an intensive weight loss program.
If a man with type 2 diabetes also suffers from erectile
dysfunction, it strongly suggests that he could well have coronary artery
disease that's not causing any symptoms, researchers report.
U.S. health regulators have
accused Vivus Inc. of misleading consumers by downplaying risks associated with
its little-used erectile dysfunction treatment called Muse. Vivus failed to
include risk information and made false claims about the drug's effectiveness
both on its Web site and in television advertisements that ran in 2003.
Prostate cancer patients underwent an operation called a bilateral
nerve-sparing retropubic radical prostatectomy. More than 90 percent of these men who
had the operation suffered from erectile
dysfunction afterwards.
A third of older men have
erectile dysfunction
and the problem only gets more common with age. The good news is that there are
many things men can do to reduce their risk of
erectile dysfunction.
The figures come from a survey of nearly 32,000 men, 53 to 90 years of age, who
participated in the Health Professionals Follow-up Study. The results are
reported in the Annals of Internal Medicine. Dr. Constance G. Bacon, from
Harvard School of Public Health, and associates found that 33 percent of the men
reported erection problems in the previous 3 months. Moreover, for each decade
beyond 50 years of age, overall sexual function, desire, and orgasm frequency
decreased sharply. Physical inactivity and obesity had a lot to do with
erectile dysfunction.
Men who ran for at least 3 hours per week or engaged in a similar amount of
exercise were 30 percent less likely to have
erectile dysfunction
than men who barely exercised at all. Similarly, non-obese men were 30 percent
less likely to develop these problems than obese men, the researchers note.
Other "risk factors" for
erectile dysfunction
included smoking, drinking alcohol, and watching television. SOURCE: Annals of
Internal Medicine August 5, 2003.
Dr. Sahelian adds: Diet also plays an important role in reducing the risk of
erectile dysfunction. I recommend eating lots of healthy, organic vegetables and
adding fish to the diet.
Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4
activities.
Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J.
Department of Urology, the 1st Hospital, Peking University, 8 Xishiku Street,
Xicheng District, Beijing 100034, China.
AIM: To clarify the mechanism of the therapeutic action of icariin on erectile
dysfunction. METHODS: PDE5 was isolated from the human platelet and PDE4
from the rat liver tissue using the FPLC system (Pharmacia, Milton Keynes, UK)
and the Mono Q column. The inhibitory effects of icariin on PDE5 and PDE4
activities were investigated by the two-step radioisotope procedure with
[(3)H]-cGMP/[(3)H]-cAMP. Papaverine served as the control drug. RESULTS: Icariin
and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4
activities. The IC(50) of Icariin and papaverine on PDE5 were 0.432 micromol/L
and 0.680 micromol/L, respectively and those on PDE4, 73.50 micromol/L and 3.07
micromol/L, respectively. The potencies of selectivity of icariin and papaverine
on PDE5 (PDE4/PDE5 of IC(50)) were 167.67 times and 4.54 times, respectively.
Icariin is a cGMP-specific PDE5 inhibitor that may be developed into
an oral effective agent for the treatment of erectile dysfunction.
The symptoms of erectile dysfunction and hypogonadism
may be early warning markers of important men's health issues, such as
cardiovascular disease, diabetes, metabolic syndrome, depression and benign
prostatic hyperplasia.
This means that early detection of erectile dysfunction may be a key factor in
early diagnosis and treatment of these serious disorders. Men have always put
their health at risk by a macho avoidance of the doctor. Often, by the time a
man decides to consult his GP, his condition is already too advanced for
successful treatment. Since the arrival of Viagra, Cialis and Levitra, this has
changed to a degree in that it has now become slightly more acceptable for men
to discuss the problem of ED and perhaps also to talk to a doctor about it. It
has now been established that the probability of men suffering from erectile
dysfunction increases rapidly with age. Low testosterone levels, or inability to
make use effectively of higher levels, results in changes in the penile tissues
causing erectile dysfunction. Moderate to long term hormone replacement can
reverse these changes and may avert the need for use of more expensive drugs.
However, hormone treatment for erectile dysfunction carries risks.
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