DMAE bitartrate benefits
Does DMAE help with memory ?

DMAE is known chemically as dimethyl-amino-ethanol. DMAE has been known in Europe by the product name Deanol for more than three decades. DMAE has two methyl groups and is chemically similar to choline. DMAE has been popular for many years in those interested in improving mental alertness and clarity of thinking.

DMAE bitartrate - Developed by Dr. Ray Sahelian, M.D.

 Suggested use: Take half or one DMAE capsule in the morning with breakfast.


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DMAE studies
Studies with DMAE go back to the 1950s. One double blind, placebo-controlled trial performed in twenty-seven patients with severe Alzheimer's disease did not show significant benefits (Fisman 1981). Another study on twenty-one patients with memory deficits was also discouraging since no improvement was found in memory (Caffarra 1980). However, DMAE was found helpful in patients with age related mental decline. DMAE was given in a dosage of 600 mg a day for four weeks to fourteen older patients (Ferris 1977). Ten patients improved and four were unchanged. The patients on DMAE had reduced depression, less anxiety, and increased motivation, but they had no improvement in memory. The researchers say, "the results thus suggest that although DMAE may not improve memory, it may produce positive behavioral changes in some senile patients." Dementia is a term that is now substituted for senility and is sometimes used to denote a severe case of age related cognitive decline.
   DMAE has been touted as an anti-aging nutrient but there is no definite proof yet that oral intake of DMAE slows aging

DMAE benefits
Most people notice being more alert and focused within a couple of hours after taking DMAE. The effects can last most of the day. A few report a higher sense of wellbeing. DMAE is recommended to be taken in the early part of the day.

DMAE side effects
DMAE is available in dosages ranging from 100 to 400 mg. It is best to start with a low dose, such as 50 to 150 mg since high doses can cause anxiety, restlessness, and muscle tenseness in the neck and shoulders. DMAE taken late in the day may cause insomnia.

Q. I took two capsules of DMAE supplement twice daily for 3 days and found these dosages can induce irritability, overstimulation, anxiety, headaches and stiffness in the jaw, neck, and shoulder.
   A. Yes, these are common DMAE side effects.

DMAE Availability
DMAE is usually sold by the name of DMAE bitartrate. A 351 mg pill of DMAE bitartrate yields 130 mg of actual DMAE. It is also available as liquid. One product contains 35 mg of DMAE per drop. Most users notice an effect from 60 to 150 mg of actual DMAE.

DMAE and Skin
A study shows DMAE cream is able to increase firmness of skin. Perhaps DMAE cream has anti-wrinkle potential. See below for the abstract.

Other mind helping supplements besides DMAE
 Alpha-GPC and Alpha-Lipoic-100 could help brain tissue.

DMAE benefits Summary
DMAE can be helpful in the elderly who have cognitive decline. This nutrient can also be taken by an adult of any age who needs to be more focused and alert.

DMAE Studies
DMAE Enhances Mood and Alertness
There are dozens of herbs and nutrients available in health food stores that influence mental function. One that has been popular for many years is DMAE, which stands for dimethyl-amino-ethanol. A recent German study evaluated the brain's electrical reaction during presentation of videoclips of 7 minute duration in 80 subjects with borderline emotional disturbance. The researchers recorded the different emotional states by having the subjects watch these film excerpts. Half of the subjects were then started on a daily dose of DMAE and the testing was repeated after 6 and 12 weeks. The testing included showing the videoclips, filling out mood questionnaires, and also evaluating the brain's electrical reaction through EEGs (electrodes placed on the scalp that measure brain activity) . The results showed that those who took the DMAE daily had less of a decrease in theta and alpha1 brain electrical activity indicating that they were more alert. Furthermore, the questionnaires revealed that those on DMAE had a better mood. The researchers conclude, "DMAE can be interpreted to induce a psychophysiological state of better feeling of wellbeing on both levels of analysis mood and electrical pattern of brain activity in subjects suffering from borderline emotional disturbance."
     Comments: Most people notice being more alert and focused within a couple of hours after taking DMAE. DMAE is available in dosages ranging from 100 to 400 mg. It is best to start with a low dose, such as 50 to 150 mg of actual DMAE since high doses can cause anxiety, restlessness, and muscle tenseness in the neck and shoulders. DMAE taken late in the day may cause insomnia.

Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states. Dimpfel W. Forschung und Entwicklung -, Kurt-Schumacher-Str. 9, D-35440 Linden, Germany. Eur J Med Res. 2003 May 30;8(5):183-91.
The psychophysiological model of provoking different emotional states by watching film excerpts with various emotional contents was used to characterize drug action in 80 subjects (male/female=50%) with threshold emotional disturbance within a randomized, group-parallel, double-blind, placebo-controlled study. Analyzing the brain's electrical reaction during presentation of 5 videoclips of 7 min duration followed by 3 minutes pause revealed a content specific representation of topographical frequency changes. This procedure was repeated after 6 and 12 weeks of daily intake of a vitamin-mineral drug combination containing dimethylaminoethanol (DMAE) or placebo. Subjects taking the active drug for 3 months developed significant less theta and alpha1 power in sensomotoric areas of the cortex. The grade of change and statistical significance was dependend on the content of the excerpt, but the pattern of changes in general remained the same. Since decreases in theta and alpha1 electrical power have been associated with increased vigilance and attention, subjects taking the drug combination obviously were more active and felt better. - Analysis of the emotional change in mood profile as induced by the TV session was achieved by completing two different quenstionaires (POMS and Bf-S). Both scores revealed a better mood for the active drug group thus corroborating the results from EEG analysis. Therefore the vitamin-mineral drug combination containing DMAE can be interpreted to induce a psychophysiological state of better feeling of wellbeing on both levels of analysis mood and electrical pattern of brain activity in subjects suffering from borderline emotional disturbance.
DMAE pill emails
Q. Should DMAE be taken every day?
   A. Our personal preference is that DMAE should not be taken every day. If DMAE gives you positive benefits, you may take a bread for a couple of days a week and if you really wanted to take another mind booster, you could try acetyl-l-carntine.

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