CoQ10 energy
benefit of CoQ10, coq10 side effects,

CoQ10 is a naturally occurring nutrient found in each cell of the body. CoQ10 was first identified by University of Wisconsin researchers in 1957. CoQ10 is found in foods, particularly in fish and meats. In addition to playing a significant role in the energy system of each of our cells, CoQ10 is a good antioxidant. Many who take CoQ10 notice that this nutrient enhances energy and mental clarity.

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For which conditions is CoQ10 helpful?
Studies with CoQ10 have mostly focused on its role in improving certain types of cardiovascular diseases, including congestive heart failure and hypertension. However, CoQ10 may also benefit those with diabetes and Parkinson's disease. .

How does CoQ10 work?
Each cell in the body needs a source of energy to survive, so cells break down sugars, fats, and amino acids to make energy. Small enclosures within cells that make this energy are called mitochondria. CoQ10 exists naturally in our mitochondria and carries electrons involved in energy metabolism. CoQ10 is essential in the production of adenosine triphosphate (ATP), the basic energy molecule of each cell.
   In the bloodstream, CoQ10 is mainly transported by lipoproteins such as LDL (low-density lipoprotein) and HDL (high-density lipoprotein). It is thought that CoQ10 is one of the first antioxidants to be depleted when LDL is subjected to oxidation. Hence, CoQ10 is an important nutrient that prevents the oxidation of lipoproteins, thus potentially reducing the risk of arteries from forming plaques and getting damaged.
   In healthy individuals, CoQ10 is found in high concentrations in the heart, kidneys, and liver.

Studies with CoQ10
Diabetes: CoQ10 may be beneficial in diabetics. It helps improve the function of endothelial cells lining blood vessels and may slightly help with blood sugar control. 

Heart Attacks: In a small trial of patients with recent myocardial infarction, CoQ10--used in addition to aspirin and cholesterol-lowering drugs--decreased the likelihood of further cardiac events for at least one year after the heart attack. The dosage of CoQ10 used in the study was 60 mg twice daily.

Heart Failure: One study in patients with heart failure showed significant improvement in functional status, clinical symptoms, and quality of life in end stage heart failure patients who were placed on CoQ10 (see bottom of page).

Hypertension: CoQ10 may help lower blood pressure by a small amount.

Cholesterol - CoQ10 may help reduce side effects from statin drugs used for high cholesterol treatment.

CoQ10 and Drug interactions
The administration of CoQ10 and warfarin does not significantly affect the anticoagulant effect of warfarin in rats. A Human trial shows Co Q10 and Ginkgo biloba do not influence the clinical effect of warfarin.

CoQ10 study
CoQ10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study.
Berman M, Erman A. Heart-Lung Transplant Unit, Rabin Medical Center, Beilinson Campus, Potah Tikva, Israel.
Clin Cardiol. 2004 May;27(5):295-9.
The number of patients awaiting heart transplantation is increasing in proportion to the waiting period for a donor. Studies have shown that coenzyme Q10 (CoQ10) has a beneficial effect on patients with heart failure. HYPOTHESIS: The purpose of the present double-blind, placebo-controlled, randomized study was to assess the effect of CoQ10 on patients with end-stage heart failure and to determine if CoQ10 can improve the pharmacological bridge to heart transplantation. A prospective double-blind design was used. Thirty-two patients with end-stage heart failure awaiting heart transplantation were randomly allocated to receive either 60 mg U/day of Ultrasome--CoQ10 (special preparation to increase intestinal absorption) or placebo for 3 months. All patients continued their regular medication regimen. Assessments included anamnesis with an extended questionnaire based partially on the Minnesota Living with Heart Failure Questionnaire, 6-min walk test, blood tests for atrial natriuretic factor (ANF) and tumor necrosis factor (TNF), and echocardiography. Twenty-seven patients completed the study. The study group showed significant improvement in the 6-min walk test and a decrease in dyspnea, New York Heart Association (NYHA) classification, nocturia, and fatigue. No significant changes were noted after 3 months of treatment in echocardiography parameters (dimensions and contractility of cardiac chambers) or ANF and TNF blood levels. The administration of CoQ10 to heart transplant candidates led to a significant improvement in functional status, clinical symptoms, and quality of life. However, there were no objective changes in echo measurements or ANF and TNF blood levels. Coenzyme Q10 may serve as an optional addition to the pharmacologic armamentarium of patients with end-stage heart failure. The apparent discrepancy between significant clinical improvement and unchanged cardiac status requires further investigation.

Serum coQ10 concentrations in healthy men supplemented with 30 mg or 100 mg coQ10 for two months in a randomized controlled study.
Zita C, Overvad K, Mortensen SA.Clinic of Geographic Medicine, Prague, Czech Republic.
Biofactors. 2003;18(1-4):185-93.
Serum CoQ10 concentrations were evaluated in healthy male volunteers supplemented with 30 mg or 100 mg CoQ10 or placebo as a single daily dose for two months in a randomized, double-blind, placebo-controlled study. Median baseline serum CoQ10 concentration in 99 men was 1.26 mg/l (10%, 90% fractiles: 0.82, 1.83). Baseline serum CoQ10 concentration did not depend on age, while borderline significant positive associations were found for body weight and smoking 1-10 cigarettes/d. Supplementation with 30 mg or 100 mg CoQ10 resulted in median increases in serum CoQ10 concentration of 0.55 mg/l and 1.36 mg/l, respectively, compared with a median decrease of 0.23 mg/l with placebo. The changes in the CoQ10 groups were significantly different from that in the placebo group, and the increase in the 100 mg CoQ10 group was significantly greater than that in the 30 mg CoQ10 group. The change in serum CoQ10 concentration in the CoQ10 groups did not depend on baseline serum CoQ10 concentration, age, or body weight.

CoQ10 supplier - Jamieson Laboratories
Jamieson laboratories, Canada's leading manufacturer of natural health products, today unveiled the newest addition to its family of industry-leading coQ10 products - Jamieson CoQ10 120 mg. (milligram), a one-a-day higher potency nutrient supplement that aids in the production of energy in all cells of the body as well supports the protection of cells from free radical damage. Jamieson CoQ10 120 mg. offers Canadian consumers 120 mg. of coQ10 or ubiquinome nutrient in each capsule - one of the highest potency formulas in the industry. Jamieson CoQ10 120 mg. is formulated from natural, fermented sources and is pharmaceutically tested to guarantee full potency and absolute clinical purity. The Jamieson CoQ10 family also includes Jamieson CoQ10 30 mg.
   Comments: Only in rare cases do people need to supplement with more than 50 mg of CoQ10 daily. Some people feel fatigued if they take more than 100 mg of CoQ10.

CoQ10 Emails
Q. Does the effectiveness of Co Q10 matter if it is taken in capsule form or if emulsified in an oil like alpha tocopherol.  I read an advertising leaflet that said not to waste money on CoQ10 tablets or capsules, because they cannot be absorbed into blood stream.
   A. There are probably differences in absorption between different CoQ10 products, and perhaps oil emulsified products are better absorbed, however, most CoQ10 supplements contain 30, 60 or 100 mg which are dosages far greater than normally needed by the body. Hence, even if 100 percent of the CoQ10 is not absorbed, practically speaking it should not make too much difference.

Q. I’ve read conflicting articles regarding the amount of CoQ10 absorbed from the intestines depending on its form. Can you tell me if there’s a difference between different product?
   A. Studies of the effectiveness of coenzyme Q10 (CoQ10) have been confusing due to the variable bioavailability of numerous CoQ10 preparations. Researchers at the Alfred Hospital and Baker Medical Research Institute, in Melbourne, Australia evaluated two different preparations of CoQ10: a soybean oil-based preparation and a complex micelle emulsion. Twelve healthy individuals received 300 mg CoQ10 daily of either preparation for 7 days in a double-blind cross-over design. Blood samples to determine serum levels of CoQ10 and lipids were taken at baseline, after 24 h and after 7 days. Both preparations induced significant increases in serum CoQ10 levels at 24 h and 7 days and there was were no differences between CoQ10 levels for the two preparations at either time point.
    Since most people take a large dose of coQ10, such as 60 or 100 mg, even if one preparation were not absorbed as well, there should still be plenty of CoQ10 to be helpful.

Q. I came across your article on CoQ10 on the internet, and was very impressed with your level of knowledge on this product. My father who resides in Vancouver, Canada has been experiencing many challenges with his heart in the past 4 years. He had a stroke after a triple bypass 3 years ago, and 10 months later he was hospitalized due to an over dose of Amiodarone recommended by his doctors. He now has a pace maker in his chest and continues to consume all the prescribed drugs. Dad is very addicted to his medication and has always been very cautious of giving the alternative medicine a try. I have been working in the nutraceuticals industry for almost ten years, and I certainly understand the importance of CoQ10. If I could convince my father and his MD that consumption of Co Q10 will have no counteraction on his medication, he may be persuaded to give this opportunity a chance. Having said that, do you have any references and/or suggestions for articles recognized by Canadian MD’s that can help me accomplish my goal?! Is there other information or resources you maybe able to share that could help my father?
   A. Our purpose with the website is to provide general information and the latest research on CoQ10, so we can't advise or try to convince anyone what to do or take. It is up to him and his doctor to read all the information that is provided on CoQ10 and come to a decision.

Q. I have prostate cancer and my doctor has prescribed that I take 10 CoQ10 per day along with other vitamins / supplements . I have been taking these for about 3 to 4 weeks and frankly I do not feel any difference. I have been taking the "naturally fermented john o'neil' 100mg CoQ10 capsules.
   A. We appreciate your email but we can't comment on individual cases, there are too many variables involved and a full medical history and exam and blood studies are required to make an accurate diagnosis and treatment plan.

Q. Hello. I have a question regarding dosage on COQ10. I recently purchased 200 mg softgels and then read Dr. Sahelian does not recommend taking this much at one time. The store will not allow me to exchange them as they are opened. Do you think I can cut them in half or is this not recommended as the liquid inside will come in instant contact with my mouth?
   A. One can use the liquid inside but a person is not obliged to take the whole amount.

Q. There was an article in November in LA Times health section about Q10. It suggested to take crystal free Q10 since it absorbs better. I read that your product comes from Japan, supposedly high quality, but it doesn’t mention crystal free.
   A. Most of the time writers of articles in magazines or newspapers are not sophisticated enough about the field of supplements to have a thorough understanding. Studies with CoQ10 thus far have been done will all types and they all show benefit without crystal free, in gel form, with various oils, and in all forms. As long as the CoQ10 product you buy is true to its label regarding the amount of CoQ10 in it, you can't go wrong using that product. Furthermore, the amount of CoQ10 that people take through supplements may be too high anyway since the body may not need the large dosages that some people are taking.

Q.  I take Lipitor 10mg, Tricor 48mg and 25mg of hydrochlorothiazide. About 10 months ago I was told I have a "paralyzed diaphragm" and lately I have lost strength in my right arm too. After reading about the benefits of coq10, I was wondering if you think my problems could be resolved by the taking of coq10 ( 50mg, 2x a day), I also am now taking vitamin C, B-50 and a multi-vitamin. I don't know what to do, all the blood work I have had comes back within normal limits and no one seems to have an answer for me.
   A. It is not possible for us to guess what benefit, if any, CoQ10 would offer. There are alternatives to high cholesterol treatment that your doctor could consider.

Q. I'm a dialysis patient. My nephrologist asked me to find out how dialysis plays a role. Does coenzyme Q 10 build up in patients that don't urinate? Is it dialyzed out? Is Coq10 metabolized in the liver or kidneys? I've had a heart attack and would like to try taking CoQ10 supplements.
   A. We found two studies regarding CoQ10 levels in dialysis patients:

Plasma levels of coenzyme Q(10), vitamin E and lipids in uremic patients on conservative therapy and hemodialysis treatment: some possible biochemical and clinical implications.
Clin Chim Acta. 2000 Feb 25;292(1-2):81-91. Istituto di Chimica e Chimica Clinica, Università Cattolica del S. Cuore, Rome, Italy.
Coenzyme Q10 CoQ10, vitamin E, total cholesterol, HDL-cholesterol (HDLC) and triglycerides were measured in the plasma of 62 patients with kidney failure, 46 under hemodialysis treatment and 16 under conservative therapy, and 95 controls. The sum of LDL-cholesterol (LDL-C) and VLDL-cholesterol (VLDL-C) was also calculated for each patient. The ratio CoQ10 / LDL-C+VLDL-C in both conservative therapy and hemodialysis populations was significantly lower compared with normal controls and remained unchanged after the dialysis treatment. On the contrary the ratio vitamin E/LDL-C+VLDL-C was normal but decreased significantly after each dialysis. Since CoQ10 is the main inhibitor of the prooxidant action of vitamin E, it was hypothesized that its decrease in both the populations examined could make the lipoproteins of these patients more vulnerable to a peroxidative attack.

CoQ10 levels, plasma lipids and peroxidation extent in renal failure and in hemodialytic patients.
Mol Aspects Med. 1994;15 Suppl:s213-9. Istituto di Chimica e Chimica Clinica, Università Cattolica del S. Cuore.
CoQ10, vitamin E, triglycerides and conjugated dienes were measured in a group of 48 patients on chronic hemodialysis, in 15 uremic patients and in a control group of 10 normal subjects. CoQ10 levels were significantly lower in both hemodialytic and uremic patients compared with the normal group whereas triglycerides were significantly higher with respect to both normal subjects and uremic patients. Conjugated dienes were significantly higher in both hemodialytic and uremic patients with respect to normal subjects. The predialytic values of vitamin E were higher in hemodialytic patients with respect to both normal subjects and uremic patients whereas the postdialytic values were in the normal range. A restoration mechanism of vitamin E after hemodialytic treatment was hypothesized.

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 Burke BE, et al. Randomized, double-blind, placebo-controlled trial of CoQ10 in isolated systolic hypertension. South Med J 2001 Nov;94(11):1112-7.
Watts GF, et al. CoQ10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia 2002 Mar;45(3):420-6.