CoenzymeQ10 benefit of CoenzymeQ10, coenzymeq10 side effects

 Coenzyme Q10 is a naturally occurring nutrient found in each cell of the body. Coenzyme Q10 was first identified by University of Wisconsin researchers in 1957. Coenzyme Q10 is found in foods, particularly in fish and meats. In addition to playing a significant role in the energy system of each of our cells, CoQ10 is a good antioxidant. Many who take Coenzyme Q10 notice that this nutrient provides energy and mental clarity.

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Coenzyme Q10 - 30 mg, 60 capsules, see CoQ10-30mg
Coenzyme Q10 - 50 mg, 60 softgels
Coenzyme Q10 - 60 mg, 60 softgels, see CoQ10-60mg
CoQ10 - 100 mg, 60 softgels
You can find CoenzymeQ10 here.



 For which conditions is Coenzyme Q10 helpful?
Studies with Coenzyme Q10 have mostly focused on its role in improving certain types of cardiovascular diseases, including congestive heart failure and hypertension. However, CoQ10 may benefit those with diabetes and Parkinson's disease. For more coenzyme q10 information.

How does Coenzyme Q10 work?
Each cell in the body needs a source of energy to survive, so cells break down sugars, fats, and amino acids to make energy. Small enclosures within cells that make this energy are called mitochondria. Coenzyme Q10 exists naturally in our mitochondria and carries electrons involved in energy metabolism. Coenzyme Q10 is essential in the production of adenosine triphosphate (ATP), the basic energy molecule of each cell.
   In the bloodstream, Coenzyme Q10 is mainly transported by lipoproteins such as LDL (low-density lipoprotein) and HDL (high-density lipoprotein). It is thought that Coenzyme Q10 is one of the first antioxidants to be depleted when LDL is subjected to oxidation. Hence, CoQ10 is an important nutrient that prevents the oxidation of lipoproteins, thus potentially reducing the risk of arteries from forming plaques and getting damaged.
   In healthy individuals, Coenzyme Q10 is found in high concentrations in the heart, kidneys, and liver.

 Benefits of Coenzyme Q10
 Diabetes: Coenzyme Q10 may be beneficial in diabetics. It helps improve the function of endothelial cells lining blood vessels and may slightly help with blood sugar control. 

Heart Attacks: In a small trial of patients with recent myocardial infarction, Coenzyme Q10--used in addition to aspirin and cholesterol-lowering drugs--decreased the likelihood of further cardiac events for at least one year after the heart attack. The dosage of CoQ10 used in the study was 60 mg twice daily.

Heart Failure: One study shows significant improvement in functional status, clinical symptoms, and quality of life in end stage heart failure patients who were placed on Coenzyme Q10 (see bottom of page).

Hypertension: Coenzyme Q10 may help lower blood pressure by a small amount.

Parkinson's Disease: A small but promising study found that coenzyme Coenzyme Q10 may help stop the nerve cell death that characterizes Parkinson's. disease. The study involved just 80 people. Half ate maple-nut flavored wafers containing various Coenzyme Q10 doses, half took a placebo for up to 16 months. By the study's end, the 23 patients on the highest daily doses had 44 percent less decline in mental function, movement and ability to perform daily living tasks than the placebo group. Research has suggested that energy-supplying structures inside cells called mitochondria may be impaired in Parkinson's disease. Patients studied had early-stage Parkinson's and took a placebo or Coenzyme Q10 in doses of 300 milligrams, 600 mgs or 1,200 mgs daily. Their symptoms were evaluated for up to 16 months. By the eighth month, the 23 patients on the highest dose showed significantly less impairment than the others. Side effects, including back pain, headaches and dizziness, were mostly mild.
    Comments: I'm surprised these patients could tolerate these very high doses of Coenzyme Q10. I have had feedback from those using high doses of Coenzyme Q10 that, in some people, there is excessive stimulant-like effect and high levels of alertness that may cause insomnia.

Experience with Coenzyme Q10
The effect from 30 mg of Coenzyme Q10 is mild, mostly consisting of a slightly higher energy level. The effects become more noticeable with 60 mg. I have taken up to 100 mg in the morning. On this dose, there is increase in energy as the day goes on, with an urge to take a long walk or be physically active. There is enhanced focus, motivation, and productivity, along with the desire to talk to people. The 100-mg dose of CoQ10, though, is too much leading to insomnia.

Coenzyme Q10 and Drug interactions
The administration of Coenzyme Q10 and warfarin does not significantly affect the anticoagulant effect of warfarin in rats. A Human trial shows Co Q10 and Ginkgo biloba do not influence the clinical effect of warfarin.

Coenzyme Q10 Side Effects and Cautions
High dosages of Coenzyme Q10 can induce restlessness and insomnia.

Coenzyme Q10 Recommendations
Coenzyme Q10 is beneficial in cardiovascular conditions and this nutrient will likely be found to play some positive role in cognitive or neurodegenerative disorders, but more studies are needed.
   It would seem appropriate to supplement with this nutrient as part of a long-term health regimen, particularly for those with cardiovascular conditions. Long-term therapy with 10 to 30 mg seems to be a reasonable option for many individuals.

Coenzyme Q10 study
 Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study.
Berman M, Erman A, Ben-Gal T, Heart-Lung Transplant Unit, Rabin Medical Center, Beilinson Campus, Potah Tikva, Israel.
Clin Cardiol. 2004 May;27(5):295-9.
The number of patients awaiting heart transplantation is increasing in proportion to the waiting period for a donor. Studies have shown that coenzyme Q10 (CoQ10) has a beneficial effect on patients with heart failure. HYPOTHESIS: The purpose of the present double-blind, placebo-controlled, randomized study was to assess the effect of coenzyme Q10 on patients with end-stage heart failure and to determine if coenzyme Q10 can improve the pharmacological bridge to heart transplantation. A prospective double-blind design was used. Thirty-two patients with end-stage heart failure awaiting heart transplantation were randomly allocated to receive either 60 mg U/day of Ultrasome--coenzyme Q10 (special preparation to increase intestinal absorption) or placebo for 3 months. All patients continued their regular medication regimen. Assessments included anamnesis with an extended questionnaire based partially on the Minnesota Living with Heart Failure Questionnaire, 6-min walk test, blood tests for atrial natriuretic factor (ANF) and tumor necrosis factor (TNF), and echocardiography. Twenty-seven patients completed the study. The study group showed significant improvement in the 6-min walk test and a decrease in dyspnea, New York Heart Association (NYHA) classification, nocturia, and fatigue. No significant changes were noted after 3 months of treatment in echocardiography parameters (dimensions and contractility of cardiac chambers) or ANF and TNF blood levels. The administration of coenzyme Q10 to heart transplant candidates led to a significant improvement in functional status, clinical symptoms, and quality of life. However, there were no objective changes in echo measurements or ANF and TNF blood levels. Coenzyme Q10 may serve as an optional addition to the pharmacologic armamentarium of patients with end-stage heart failure. The apparent discrepancy between significant clinical improvement and unchanged cardiac status requires further investigation.

Serum Coenzyme Q10 concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q10 for two months in a randomised controlled study.
Zita C. Clinic of Geographic Medicine, Prague, Czech Republic.
Serum coenzyme Q10 (Q10) concentrations were evaluated in healthy male volunteers supplemented with 30 mg or 100 mg Q10 or placebo as a single daily dose for two months in a randomised, double-blind, placebo-controlled study. Median baseline serum Q10 concentration in 99 men was 1.26 mg/l (10%, 90% fractiles: 0.82, 1.83). Baseline serum Q10 concentration did not depend on age, while borderline significant positive associations were found for body weight and smoking 1-10 cigarettes/d. Supplementation with 30 mg or 100 mg coenzyme Q10 resulted in median increases in serum coenzyme Q10 concentration of 0.55 mg/l and 1.36 mg/l, respectively, compared with a median decrease of 0.23 mg/l with placebo. The changes in the Q10 groups were significantly different from that in the placebo group, and the increase in the 100 mg coenzyme Q10 group was significantly greater than that in the 30 mg Q10 group. The change in serum coenzyme Q10 concentration in the Q10 groups did not depend on baseline serum coenzyme Q10 concentration, age, or body weight.

 Coenzyme Q10 emails
Q. I just wanted to mention that I recently began taking Coenzyme Q10 and noticed that there was a significant change in my health. I've felt so much better physically and mentally. My ability to focus had been lacking in the past year or so but after taking Coenzyme Q10 I've been able to think clearer. My energy levels are higher, and although I've given up eating beef, I'm noticing a difference in my physical self.

Q. Is Coenzyme Q10 helpful in maintaining healthy gums particularly for those who are lax in daily flossing. If so, what dosage is recommended.
   A. Although a couple of studies have indicated that CoQ10 may be helpful in gum disease, the most important way to keep healthy gums is to remove the food particles that are stuck between teeth. This is best accomplished by flossing. You may wish to keep your floss by your bed at night or near your favorite sofa while watching TV before bed and thus have a reminder to floss at night. I personally prefer flossing before brushing.

Q. Does the effectiveness of Coenzyme Q10 matter if it is taken in capsule form or if emulsified in an oil like alpha tocopherol. I read an advertising leaflet that said not to waste money on Coenzyme Q10 tablets or capsules, because they cannot be absorbed into blood stream.
   A. There are probably differences in absorption between different CoQ10 products, and perhaps oil emulsified products are better absorbed, however, most CoQ10 supplements contain 30, 60 or 100 mg which are dosages far greater than normally needed by the body. Hence, even if 100 percent of the CoQ10 is not absorbed, practically speaking it should not make too much difference.

Burke BE, et al. Randomized, double-blind, placebo-controlled trial of Coenzyme Q10 in isolated systolic hypertension. South Med J 2001 Nov;94(11):1112-7.
Watts GF, et al. Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia 2002 Mar;45(3):420-6.

Q. I have just gone through your website and read about Coenzyme Q10. Sir, I am suffering from some type of neurological disorder, whereby doctor describe this as a cerebellar ataxia. my symtoms are imbalance in walking, trembling of hands, slurred speech and others. here in my country nobody know about this supplement. My MRI findings are cerebral atrophy. Sir would it be harmful for me to take Coenzyme Q10 in small quatity, say 30 mg. I would like to consume coenzyme q10 30 mg and see whether the symptoms are improving.
   A. We have not come across any side effects with low dose coenzyme q10 at 30 mg, and if your doctor approves you can try this supplement.

Q. Regarding CoQ10 and neuropathy, here’s a study that found that it worsened neuropathy. I’ve been taking coenzyme q10, and have developed numbness in my toes, so am thinking of cutting back. Of course it could be due to other things, but will see what happens. Anyway, perhaps you’ll want to add this to your page. "One preliminary study of CoQ 10 for people undergoing treatment for HIV found conflicting results; the supplement appeared to improve general well-being, but it did not protect mitochondria (as the researchers had hoped it would) and actually seemed to worsen symptoms of nerve-related pain (peripheral neuropathy). Christensen ER, Stegger M, Jensen-Fangel S, et al. Mitochondrial DNA levels in fat and blood cells from patients with lipodystrophy or peripheral neuropathy and the effect of 90 days of high-dose coenzyme Q treatment: a randomized, double-blind, placebo-controlled pilot study. Clinical Infectious Diseases. 2004;39:1371-1379.

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