Petadolex contains the patented extract of butterbur that supports healthy blood vessel tone in the brain, as well as normal blood flow in the brain.* Butterbur has been the subject of several placebo-controlled clinical studies.
Petadolex ( Butturbur ) 60 Softgels -
Enzymatic Therapy
Petadolex contains the patented extract of butterbur that supports healthy
blood vessel tone in the brain, as well as normal blood flow in the
brain.* Butterbur has been the subject of several placebo-controlled
clinical studies.
Petadolex is standardized to contain 15% of butterbur's key ingredient, petasin. It's also guaranteed to be pyrrolizidine alkaloid (PA) free, so you can use it with confidence. PA's are toxic compounds that can harm the liver. Studies demonstrate patented Petadolex is safe and well tolerated.
Butterbur
Supplement Facts:
Purple Butterbur (Petasites hybridus) 50 mg
(Petadolex brand) Root Extract standardized to contain 7.5 mg petasins and to be free of pyrrolizidine alkaloids (PAs)
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Active ingredients in
Butterbur
Petasin, a kind of sesquiterpene ester, appears to be a major active compound of
Butterbur
extract. It has inhibitory activities on leukotriene generation in
eosinophils and neutrophils. This indicates that it may have anti-inflammatory and
anti-allergy properties.
Butterbur
may be helpful for seasonal allergic rhinitis.
Butterbur
also helps reduce smooth muscle spasm.
Medical uses for
Butterbur
Migraine Headache: Two clinical studies using 50 mg and 75 mg of a standardized
Butterbur
extract twice daily for 12 weeks demonstrated its effectiveness as a
prophylactic treatment for migraines. When used to treat migraines, administration is
prophylactic and supplementation should be carried out daily for a few weeks and then
tapered until migraine incidence begins to increase.
Butterbur may work by preventing
peptidoleukotriene biosynthesis.
Butterbur root extract and music therapy in the
prevention of childhood migraine: An explorative study.
Eur J Pain. 2007 Jul 27; Department of Child and Adolescent Psychiatry,
University of Heidelberg, Blumenstrasse 8, D-69115 Heidelberg, Germany.
This study was to assess efficacy of a butterbur root extract Petadolex and
music therapy in primary school children with migraine. Following a 8-week
baseline patients were randomized and received either Petadolex butterbur root
extract, music therapy or placebo over 12 weeks. Butterbur root extract and
music therapy might be superior to placebo and may represent promising treatment
approaches in the prophylaxis of paediatric migraine.
Asthma and Bronchitis: Various parts of the
Butterbur
plant have been used for centuries to treat
bronchial
asthma and
whooping cough. Butterbur's
possible effectiveness in treating respiratory disorders such as asthma and bronchitis is
attributed to the antispasmodic and anti-inflammatory properties of the petasin
constituent. (see below)
Gastrointestinal Disorders: A German study found extracts of
butterbur
blocked ethanol-induced gastric damage and reduced ulcerations of the small
intestine caused by indomethacin, an anti-inflammatory drug used to treat arthritic
conditions. The results of this study were attributed to inhibition of lipoxygenase
activity and leukotriene biosynthesis.
Butterbur
Safety
Butterbur
has not been studied extensively enough to determine its side effects.
Butterbur
Dosage
Typically,
Butterbur
extracts are standardized to contain a minimum of 7.5 mg of
petasin and isopetasin. The adult dosage ranges from 50-100 mg twice daily with meals.
Enzymatic Therapy -
Petadolex, 60 Softgels
Purple Butterbur (Petasites hybridus) (Petadolex brand) Root Extract
Butterbur
study
Petasites hybridus (Butterbur root) extract in the treatment of asthma - an open
trial.
Danesch UC.
University of Heidelberg, Germany; past research position, Stanford School of
Medicine; Research and development, Weber and Weber. Correspondence address:
Muenchner Strasse 13, D-82061, Neuried, Germany.
Altern Med Rev. 2004 Mar;9(1):54-62.
The efficacy and tolerability of a butterbur root extract (Petadolex) for the
treatment of asthma was analyzed in a prospective, non-randomized, open trial.
Subjects included 64 adults and 16 children/adolescents treated for two months
with the extract, followed by two months during which the intake of the extract
was optional. Concomitant asthma medication was permitted. The number, duration,
and severity of asthma attacks decreased, while peak flow, forced expiratory
volume (FEV1), and all measured symptoms improved during therapy. In addition,
more than 40 percent of patients using asthma medications at baseline reduced
intake of these medications by the end of the study. This study suggests the
Butterbur
extract Petadolex is an effective and safe therapy for the
treatment of asthma.
A placebo-controlled evaluation of butterbur
and fexofenadine on objective and subjective outcomes in perennial allergic
rhinitis.
Lee DK, Gray RD, Robb FM et al.
Clin Exp Allergy. 2004;34:646-9.
Summary Background There are presently no placebo-controlled data
regarding the effects of butterbur on subjective and objective outcomes in
patients with perennial allergic rhinitis. Objective We performed a
placebo-controlled evaluation of the effects of
Butterbur and fexofenadine (FEX) on
subjective and objective outcomes in patients with perennial allergic rhinitis.
Methods Sixteen patients with perennial allergic rhinitis and house dust mite
sensitization were randomized in double-blind cross-over fashion to receive for
1 week either Butterbur
50 mg twice daily, FEX 180 mg once daily and placebo (PL) once
daily, or PL twice daily. The peak nasal inspiratory flow (PNIF) response to
adenosine monophosphate (AMP) challenge administered as a single 400 mg/mL dose
was measured over a 60-min period after challenge, and domiciliary total nasal
symptom score was recorded. Results Pre-challenge values for mean+/-SEM PNIF
(L/min) were not significantly different comparing all groups; BB (138+/-8), FEX
(140+/-9), and PL (138+/-8). The maximum % PNIF fall from baseline after nasal
AMP challenge was significantly attenuated (P<0.05) compared to PL (46+/-3),
with BB (34+/-3) and FEX (39+/-3). The area under the 60-min time-response curve
(%.min) was also significantly attenuated compared to PL (1734+/-156),
with Butterbur
(1052+/-258) and FEX (1194+/-161). There was also a significant
reduction in total nasal symptom score with BB (1.8+/-0.4) and FEX
(1.8+/-0.4), compared to PL. There were no significant differences
between Butterbur
and FEX for any outcomes. Conclusion BB and FEX, in comparison to PL,
were equally effective in attenuating the nasal response to AMP and in improving
nasal symptoms, highlighting a potential role for BB in the treatment of
allergic rhinitis.
Safety of a patented special butterbur root extract for migraine prevention.
Danesch U, Rittinghausen R.
Weber and Weber, Inning, Germany.
Headache. 2003 Jan;43(1):76-8.
To report on the safety of a patented special butterbur root extract
used for migraine prevention. Two placebo-controlled clinical trials
have been conducted supporting the beneficial use in humans. Results
from acute, subchronic and chronic animal toxicity studies as well as from
mutagenicity studies are reported. Safety data gained from clinical trials,
postmarketing surveillance studies and pharmacovigilance are evaluated and
discussed. The patented special butterbur root extract is safe for
the treatment in humans.
Butterbur questions
Q. Can Butterbur Petadolex be given to 4 yr old? If so what would the dosage be?
I am at my wits end trying to find something safe to treat my son with for his
seasonal allergies with asthmatic cough. As of now he is on Flovent 2 puffs 2
times a day every day starting from October through March and Albuterol as
needed. The Flovent is NOT an option anymore for me it has changed my son’s
behavior for the worse and the Albuterol is not a preventive. We have tried
Singulair and it does the same as Flovent. I want something safe that isn’t
going to affect my son’s behavior but will do its job so that he isn’t miserable
during the time mentioned above that he is to take the preventive every year.
This will be his second year using the Flovent and I have done tons of research
and none of the inhalers or respules will guarantee no change in behavior.
Actually none of the them actually list on their packaging or inform doctor’s of
these side affects.
A. Unfortunately, we are not familiar with the use of butterbur
extract in children so we don't know if it works or what the appropriate and
safe dosages would be. Consider this
asthma page.
Home - Tribulus terrestris
extract see also
books page for
additional links
butterbur study