Boswellia Serrata
pill
Boswellia extract research information, boswellia tree info and boswellia dosage
Boswellia is an Ayurvedic plant that contains anti-inflammatory
triterpenoids called boswellic acids. Boswellic acid and its derivatives have
anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities. Dried
extracts of the resin of the Boswellia serrata tree have been used since
antiquity in India to treat inflammatory conditions.
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boswellia information.
Mechanism of Action of Boswellia
Boswellia may inhibit proinflammatory 5-lipoxygenase products and blockage of
leukotriene synthesis.
Boswellia Extract , 65% Boswellic
Acids,
Nature's Way
Boswellia extract is standardized to 65% boswellic
acids, with the researched clinical dose used to support joint health and
mobility. Boswellia Extract is concentrated from the specially processed resins
and gums of the Boswellia serratta tree. The benefits of boswellia serrata are due to
the presence of four triterpene acids, especially Beta boswellic acid. This
Boswellia Extract is carefully standardized to contain at least 65% boswellic
acids.
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Boswellia Supplement Facts:
Boswellia serratta dried extract - 307 mg
Yielding 65% extract, yielding: 200 mg Boswellic Acids
Suggested Use: One tablet boswellia extract one or two times daily with a meal.
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Potential benefits of boswellia serrata
Boswellia serrata is commonly used in Indian system of medicine (Ayurvedic) as
an anti-inflammatory, analgesic, anti-arthritic and anti-proliferative agent.
Asthma -- In a double-blind, placebo-controlled trial, the use of 300 mg of boswellia 3 times daily led to improvement in signs and symptoms of asthma,
including a reduction in asthma attacks.
Inflammatory Bowel Disease -- In one study of 30 patients aged 18-48
with chronic colitis, 20 were given boswellia extract 300 mg 3 times a week for
6 weeks, and the other 10 were given sulfasalazine, 1 g three times a day. Of
the 20 treated with boswellia, 14 went into remission, as did 4 of the 10
treated with the drug. Patients were studied at the Department of Medicine, Medical College
Jammu, J&K, India suffered from chronic colitis characterized by vague lower abdominal
pain, bleeding per rectum with diarrhoea and palpable tender descending and sigmoid colon.
The inflammatory process in colitis is associated with increased formation of leukotrienes
causing chemotaxis, chemokinesis, synthesis of superoxide radicals and release of
lysosomal enzymes by phagocytes. The key enzyme for leukotriene biosynthesis is
5-lipoxygenase. Boswellic acids were found to be non-redox, non-competitive specific
inhibitors of the enzyme 5-lipoxygenase. (see research update
below)
Osteoarthritis -- boswellia is helpful
An Ayurvedic herbal combination of ashwagandha,
boswellia , and curcumin was evaluated in a randomized, double-blind, placebo
controlled, cross-over study in patients with
osteoarthritis. Treatment with
this formulation produced a significant drop in severity of pain.
Boswellia Dosage
No guidelines have been established as to the ideal dosage of boswellia. One option
is to take boswellia 300 to 500 mg 2 or 3 times a day of an extract standardized to
contain 30 to 40% boswellic acids. The full effect may take several weeks.
Boswellia tree
Boswellia, or salai guggal is a standardized powder extract of the gum of
the Boswellia tree ( Boswellia serrata ), The Boswellia tree is a balsamic
tree that secretes aromatic oleoresins which are collected, when they dry,
into a gum, after exuding from cuts in the bark.
Boswellia study
Efficacy and tolerability of Boswellia serrata extract in
treatment of osteoarthritis of knee--a randomized double blind placebo
controlled trial.
Kimmatkar N. Phytomedicine. 2003
Jan;10(1):3-7.
MS Orthopedics, Indira Gandhi Medical College, Nagpur, India.
Osteoarthritis is a common, chronic, progressive, skeletal, degenerative
disorder, which commonly affects the knee joint. Boswellia serrata tree is
commonly found in India. The therapeutic value of its gum (guggulu) has been
known. It posses good anti-inflammatory, anti-arthritic and analgesic activity.
A randomized double blind placebo controlled crossover study was conducted to
assess the efficacy, safety and tolerability of Boswellia serrata Extract
in 30 patients of osteoarthritis of knee, 15 each receiving active drug or
placebo for eight weeks. After the first intervention, washout was given and
then the groups were crossed over to receive the opposite intervention for eight
weeks. All patients receiving drug treatment reported decrease in knee pain,
increased knee flexion and increased walking distance. The frequency of swelling
in the knee joint was decreased. Radiologically there was no change. The
observed differences between drug treated and placebo being statistically
significant, are clinically relevant. Boswellia serrata Extractwas well tolerated by the subjects
except for minor gastrointestinal ADRs. Boswellia serrata Extractis recommended in the patients of
osteoarthritis of the knee with possible therapeutic use in other arthritis.
Boswellia beneficial in patients with chronic colitis
Boswellia is the
gummy resin of the boswellia tree native to India and used for centuries by
Ayurvedic doctors. It has attracted a lot of attention in the world medical
community boswellia has been found in studies to be helpful in arthritis,
asthma, and to also lower levels of fats and cholesterol in the blood. A study
conducted at the Department of Medicine, Medical College Jammu, in India
evaluated patients with chronic colitis characterized by vague lower abdominal
pain, rectal bleeding with diarrhea and tender colon. Conditions such as Crohn’s
disease and ulcerative colitis are considered to fall in the category of chronic
colitis. Thirty patients, 17 males and 13 females with chronic colitis were
included. Twenty patients were given a preparation of the gum resin of boswellia
(900 mg daily divided in three doses for 6 weeks) and ten patients were given
sulfasalazine (3 gm daily divided in three doses for 6 weeks) and served as
controls. Sulfasalazine is a common pharmaceutical drug used to treat colitis.
At the end of 6 weeks, seventy percent of patients treated with Boswellia gum
resin went into remission while in case of sulfasalazine, the remission rate was
forty percent.
Comments: Boswellia is sold in dosages ranging
from 300 to 600 mg per capsule. Most products are standardized to the active
compounds known as boswellic acids, commonly at 65 percent. A total daily amount
of 700 mg to 1,000 mg divided in two or three doses is appropriate.
Boswellia carteri
Cancer chemopreventive effects and cytotoxic activities of the triterpene acids
from the resin of Boswellia carteri.
Biol Pharm Bull. 2006 Sep;29(9):1976-9. Akihisa T,
et al.
College of Science and Technology, Nihon University, Tokyo, Japan.
Fifteen triterpene acids, viz., seven of the beta- boswellic acids (ursane-type)
(1-7), two of the alpha- boswellic acids (oleanane-type) (8, 9), two of the
lupeolic acids (lupane-type) (10, 11), and four of the tirucallane-type (12-14,
16), and two cembrane-type diterpenes (17, 18), isolated from the MeOH extract
of the resin of Boswellia carteri (Burseraceae), together with a triterpene acid
15 (the acetyl derivative of 14), were examined for their inhibitory effects on
the induction of Epstein-Barr virus early antigen. On evaluation
against the EBV-EA activation induced by TPA, seven compounds, 2, 10, 11, and
13-16, showed potent inhibitory effects on EBV-EA induction. Upon evaluation
against activation of NOR 1, five compounds, 7, 13, and 14-16, showed potent
inhibitory effects. Further, fifteen compounds, 1-7, 9-11, 13-15, 17, and 18,
exhibited potent cytotoxic activities with IC(50) values of 4.1-82.4 muM against
all of the three human neuroblastoma cells tested.
Anti-inflammatory activities of the
triterpene acids from the resin of Boswellia carteri.
J Ethnopharmacol. 2006 Sep 19;107(2):249-53. Ichimaru Pharcos Company Ltd.,
318-1 Asagi, Motosu, Gifu 501-0475, Japan.
Boswellic acids are the main well-known active components of the resin of
Boswellia carteri (Burseraceae) and these are still dealing with the
ethnomedicinal use for the treatment of rheumatoid arthritis and other
inflammatory diseases. Although several studies have already been reported on
the pharmacological properties, especially on the anti-inflammatory activity, of
Boswellia carteri resin and boswellic acids, the ethnomedicinal importance of
Boswellia carteri and its components, boswellic acids, prompted us to undertake
detailed investigation on the constituents of the resin and their
anti-inflammatory activity. Fifteen triterpene acids, viz., seven of the beta-boswellic
acids (ursane-type) (1-7), two of the alpha-boswellic acids (oleanane-type) (8,
9), two of the lupeolic acids (lupane-type) (10, 11), and four of the
tirucallane-type (12-14, 16), along with two cembrane-type diterpenes (17, 18),
were isolated and identified from the methanol extract of the resin of Boswellia
carteri.
Boswellia questions
Q. My question is in regards to boswellia extracts. Are there any known
interactions with psychotropic drugs or mood stabilizer medications?
A. There are thousands of
prescription medications and it is impossible to know for certain how each one
reacts with the countless supplements and formulas available over the counter.
As a general rule, a safe way to begin is to take half a capsule of boswellia
the first day with breakfast, and a full one the next day with breakfast if no
side effects have occurred. We suggest medical supervision or approval.
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