information, side effects, safety and caution, use for cognitive improvement in
the young, middle aged, and older individuals
Alzeimer's disease treatment
March 3 2014
Acetyl-L-carnitine is a natural supplement which raises ATP
levels and protects mitochondria. This nutrient has mind boosting potential.
Users find that they think clearer and have more mental stamina.
A combination of hoodia, ginger, cinnamon, green tea extract, spirulina, acetylcarnitine, choline, guggul, and several other herbs and nutrients, as found in Diet Rx, is a very effective herbal diet pill for appetite suppression. Users of Diet Rx are very satisfied..
Acetyl L Carnitine 300 mg
Click here buy AcetylCarnitine Alpha lipoic acid supplements, to see information on Mind Power Rx, or to sign up to a free health newsletter
For more information, see acetyl carnitine by medical doctor Ray Sahelian, M.D.
Mechanism of action
Acetyl carnitine (also spelled acetyl-l-carnitine) and carnitine play several important roles in the human body. These nutrients shuttle acetyl groups and fatty acids into mitochondria for energy production. Without carnitine, fatty acids cannot easily enter into mitochondria. The acetyl group of acetyllcarnitine is used to form acetyl-CoA, the most important intermediary in the generation of energy from amino acids, fats, and carbohydrates. Therefore, acetyllcarnitine serves as an energy reservoir of acetyl groups and both acetyllcarnitine and carnitine help improve energy production. The acetyl group of acetyl carnitine is also used to make the important brain chemical acetylcholine. Some studies suggest that perhaps acetyllcarnitine can even act as a neurotransmitter itself.
Those who take carnitine pills notice an increase in physical energy levels, but not as much mental energy. acetyllcarnitine has a significantly more immediate and noticeable mental effect than carnitine.
Acetyl carnitine research shows:
In aging rats, chronic administration of this brain nutrient increases cholinergic synaptic transmission and consequently enhances learning capacity. The memory of aging rats is rejuvenated by giving them a combination of acetyllcarnitine and lipoic acid. Another potent free radical scavenger is carnosine product.
Potential Benefits of acetyl carnitine according to published studies:
Acetyllcarnitine may improve mental fatigue in those who suffer from chronic fatigue syndrome
Some patients with multiple sclerosis are helped by acetyl carnitine, which reduces their fatigue.
Acetyllcarnitine is a promising treatment for those with diabetic neuropathy
May reduce alcohol-induced cellular damage to organs.
May be helpful in geriatric patients with mild depression.
Acetyl carnitine improves the function of mitochondria, the organelles within cells that are involved in energy production.
Is more effective than tamoxifen in the therapy of acute and early chronic Peyronie's disease.
May help individuals with degenerative cerebellar ataxia.
Acetyllcarnitine is suitable for clinical use in the prevention of neuronal death after peripheral nerve trauma.
May be helpful in those with Alzheimer's disease. acetyllcarnitine protects against amyloid-beta neurotoxicity.
Acetyllcarnitine short term side effects, safety, risks, adverse events
The mind boosting effect of acetyllcarnitine is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement. acetyllcarnitine may be used as an overall mind booster. The typical dosage is 250 to 500 mg once a day, preferably in the early part of the day. Side effects of overstimulation and nausea may occur at dosages greater than 300 to 500 mg.
Availability of acetylcarnitine supplements over the counter, in health food stores
You will often find acetylcarnitine in these dosages
Acetylcarnitine 250 mg per capsule
500 mg per capsule
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
J Neurol Sci. 2009; Shenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, Gasimov E, Alvarez LM, Ames BN, Lamanna JC, Aliev G. Department of Biology and Electron Microscopy Research Center, University of Texas at San Antonio, San Antonio, TX, USA.
We measured age-dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age-matched wild-type (WT) mice by use of [(14)C] iodoantipyrene autoradiography. ApoE4 associated factors reduce CBF gradually to create brain hypoperfusion when compared to WT, and the differences in CBF are greatest as animals age from 6-weeks to 12-months. Transmission electron microscopy with colloidal gold immunocytochemistry showed structural damage in young and aged microvessel endothelium of ApoE4 animals extended to the cytoplasm of perivascular cells, perivascular nerve terminals and hippocampal neurons and glial cells. These abnormalities coexist with mitochondrial structural alteration and mitochondrial DNA overproliferation and/or deletion in all brain cellular compartments. Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-l-carnitine and R-alpha-lipoic acid. Our findings indicate that ApoE4 genotype-induced mitochondrial changes and associated structural damage may explain age-dependent pathology seen in AD, indicating potential for novel treatment strategies in the near future.
Exploratory open label, randomized study of acetyl- and
propionylcarnitine in chronic fatigue
Vermeulen RC, Scholte HR. Research Center Amsterdam, Amsterdam, Netherlands.
Psychosom Med. 2004.
We compared the effects of acetyl carnitine, propionylcarnitine and both compounds on the symptoms of chronic fatigue syndrome (CFS). In an open, randomized fashion we compared 2 g/d acetyl-L-carnitine, 2 g/d propionyl-L-carnitine, and its combination in 3 groups of 30 CFS patients during 24 weeks. Effects were rated by clinical global impression of change. Secondary endpoints were the Multidimensional Fatigue Inventory, McGill Pain Questionnaire, and the Stroop attention concentration test. Scores were assessed 8 weeks before treatment; at randomization; after 8, 16, and 24 weeks of treatment; and 2 weeks later. Clinical global impression of change after treatment showed considerable improvement in 59% of the patients in the acetyllcarnitine group and 63% in the propionylcarnitine group, but less in the acetyllcarnitine plus propionylcarnitine group (37%). acetyl carnitine significantly improved mental fatigue (p =.015) and propionylcarnitine improved general fatigue. Attention concentration improved in all groups, whereas pain complaints did not decrease in any group. Two weeks after treatment, worsening of fatigue was experienced by 52%, 50%, and 37% in the acetyllcarnitine, propionylcarnitine, and combined group, respectively. In the acetyllcarnitine group, but not in the other groups, the changes in plasma carnitine levels correlated with clinical improvement. Acetyllcarnitine and propionylcarnitine showed beneficial effect on fatigue and attention concentration. Less improvement was found by the combined treatment. acetyllcarnitine had main effect on mental fatigue and propionylcarnitine on general fatigue.
Effects of acetyl carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors.
Bianchetti A. Geriatric Research Group, Brescia, Italy. Curr Med Res Opin. 2003.
acetyllcarnitine is a compound acting as an intracellular carrier of acetyl groups across inner mitochondrial membranes. It also appears to have neuroprotective properties and it has recently been shown to reduce attention deficits in patients with Alzheimer's disease (AD) after long-term treatment. We performed an open study to evaluate the effect of acetyl carnitine (2 g/day orally for 3 months) in association with donepezil or rivastigmine in 23 patients with mild AD who had not responded to treatment with acetylcholinesterase inhibitors (AChE-I). Clinical effects were evaluated by assessing cognitive functions, functional status and behavioural symptoms. The response rate, which was 38% after AChE-I treatment, increased to 50% after the addition of acetyllcarnitine, indicating that the combination of these two drugs may be a useful therapeutic option in AD patients. These data do not permit a conclusion as to the possible mechanism of action of the association of the two treatments.
Acetyl carnitine product emails
Q. I have been reading books and various articles for years. Iím a big fan of nutrition, health, and fitness so I find them interesting and educational. I have been a good customer of my local health food store over the years. I have purchased scores of vitamins/minerals/amino acids and herbs of all types. Mostly I buy herbs for energy as well as anti-oxidants to treat a rare disease that I have. I usually end up throwing away most of them after a couple of weeks use. However, I have been taking Alpha Lipoic Acid and acetyllcarnitine (500 mg) in the morning on an empty stomach for months now. My mind is clearer, my skin looks better, and my energy level is higher that it has been in years. It also affects my libido in a positive way. I do not work in the nutrition industry. Someone could argue this could be some sort of placebo effect, but it has been such a dramatic effect I donít think that it is placebo effect at all.
Q. Is it okay to take acetyl carnitine daily for months and years?
A. We are not sure if anybody knows the answer to the consequences of chronic acetyllcarnitine intake. With acetyllcarnitine, as with most supplements, We often recommend taking a break from use once in a while. I would also try to limit acetyllcarnitine intake to 300 mg or less a few times a week.
Q. I plan to take acetyl carnitine as a mind booster. How quickly should I expect to notice an effect and what is a recommended dose? Does it also have other benefits?
A. The mind boosting effect of acetyllcarnitine is often noticed within a few hours, or less. Most people report feeling mentally sharper, having more focus and being more alert. I personally notice an effect within 2 hours. Studies in aging rats shows chronic administration of acetyl-l-carnitine increases cholinergic synaptic transmission and consequently enhances learning capacity. The memory of aging rats is rejuvenated by giving them a combination of acetyl carnitine and lipoic acid. Acetyl-l-carnitine may reduce alcohol-induced cellular damage to organs, be helpful in geriatric patients with mild depression, and protects against amyloid-beta neurotoxicity, which may be helpful in Alzheimer's disease. Most pills come in 250 or 500 mg. I find that many patients notice benefits at a dosage ranging from 100 to 500 mg taken a few minutes before breakfast. It's a good idea to take a break for a week or so each month.
Q. Does taking acetylcarnitine have
anti aging benefits?
A. There is no research that can tell us whether using this supplement leads to antiaging benefits. It is possible that high dosages could shorten lifespan and tiny amounts could be helpful. This is just a guess.
Q. Does acetylcarnitine help
A. It is possible that regular use of acetylcarnitine may help erectile function in some users, but this nutrient is not specific to erection improvement as are other aphrodisiac herbs. For sexual enhancement, see Tongkat Ali website or yohimbe article.
Q. I recently bought Club natural creatine 700mg and
Acetyl-L carnitine 300mg. I forgot both in the car in a hot day for few hours.
Are they still okay to use?
A. it is difficult to know how high the temp was in the car, if it was over 100 degrees for many hours there may have been some changes to the chemical composition.
Just a question on acetyl-L-carnitine pills. Is there
any natural foods that contain this natural supplement in a natural form such as
any types of vegetables, fruits or meats that you are aware of? Or, any foods
that are supplemantal to the acetyl-L-carnitine?
We are not aware of any foods that contain any substantial amount of acetyl l-carnitine. The best option is to take an acetyl l-carnitine pill, although there are many other supplements that are beneficial for memory and mental enhancement.
Is there an acetyllcarnitine study
that combines this nutrient with an aphrodisiac herb called
We have not come across such a study. Most researchers have focused their attention with the use of acetyl carnitine for Alzeimer's disease or cognivite enhancement.
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